Jackson J, McDonald M, Casey E, Kelleher S, Murray A, Temperley I, Shanik G, Feighery C, Jackson F
Dept. of Immunology/Pathology, St. James's Hospital, Dublin, Ireland.
J Rheumatol. 1990 Nov;17(11):1523-4.
We report a patient with mixed connective tissue disease (MCTD) who presented with thrombosis of the right femoral artery in association with antiphospholipid antibodies (aPL). When treated surgically and with heparin prophylaxis, she developed heparin induced thrombocytopenia and thrombosis which necessitated amputation of a lower limb. Thus our patient developed 2 separate groups of autoantibodies associated with thrombotic events. Our case highlights an association between thrombosis, aPL and MCTD. Furthermore, it emphasizes a need for intensive monitoring when hypercoaguable individuals with connective tissue disorders are treated with heparin.
我们报告了一名混合性结缔组织病（MCTD）患者，该患者出现右股动脉血栓形成，并伴有抗磷脂抗体（aPL）。在接受手术治疗和肝素预防时，她发生了肝素诱导的血小板减少症和血栓形成，这使得不得不截肢一条下肢。因此，我们的患者出现了两组与血栓形成事件相关的自身抗体。我们的病例突出了血栓形成、aPL与MCTD之间的关联。此外，它强调了在对患有结缔组织疾病的高凝个体进行肝素治疗时需要进行密切监测。
