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由于自身免疫性疾病导致的大型腿部溃疡。

Large leg ulcers due to autoimmune diseases.

机构信息

B Shine Department of Rheumatology, Rambam Health Care Campus and Rappaport Faculty of Medicine, Technion, Haifa, Israel.

出版信息

Med Sci Monit. 2011 Jan;17(1):CS1-7. doi: 10.12659/msm.881308.

DOI:10.12659/msm.881308
PMID:21169912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3524676/
Abstract

BACKGROUND

Large leg ulcers (LLU) may complicate autoimmune diseases. They pose a therapeutic challenge and are often resistant to treatment. To report three cases of autoimmune diseases complicated with LLU.

CASE REPORT

Case 1. A 55-year old woman presented with long-standing painful LLU due to mixed connective tissue disease (MCTD). Biopsy from the ulcer edge showed small vessel vasculitis. IV methylprednisolone (MethP) 1 G/day, prednisolone (PR) 1mg/kg, monthly IV cyclophosphamide (CYC), cyclosporine (CyA) 100mg/day, IVIG 125G, ciprofloxacin+IV Iloprost+enoxaparin+aspirin (AAVAA), hyperbaric oxygen therapy (HO), maggot debridement and autologous skin transplantation were performed and the LLU healed. Case 2. A 45-year old women with MCTD developed multiple LLU's with non-specific inflammation by biopsy. MethP, PR, hydroxychloroquine (HCQ), azathioprine (AZA), CYC, IVIG, AAVAA failed. Treatment for underlying the LLU tibial osteomyelitis and addition of CyA was followed by the LLU healing. Case 3. A 20-year-old man with history of polyarteritis nodosa (PAN) developed painful LLU's due to small vessel vasculitis (biopsy). MethP, PR 1 mg/kg, CYC, CyA 100 mg/d, AAVAA failed. MRSA sepsis and relapse of systemic PAN developed. IV vancomycin, followed by ciprofloxacin, monthly IVIG (150 g/for 5 days) and infliximab (5 mg/kg) were instituted and the LLU's healed.

CONCLUSIONS

LLU are extremely resistant to therapy. Combined use of multiple medications and services are needed for healing of LLU due to autoimmune diseases.

摘要

背景

大肢体溃疡（LLU）可能会使自身免疫性疾病复杂化。它们构成了治疗挑战，并且经常对治疗有抵抗力。报告三例自身免疫性疾病合并 LLU 的病例。

病例报告

病例 1. 一名 55 岁女性因混合性结缔组织病（MCTD）出现长期疼痛性 LLU。溃疡边缘的活检显示小血管血管炎。静脉注射甲基强的松龙（MethP）1 G/天、泼尼松龙（PR）1mg/kg、每月静脉注射环磷酰胺（CYC）、环孢素（CyA）100mg/天、静脉注射免疫球蛋白（IVIG）125G、环丙沙星+静脉 Iloprost+依诺肝素+阿司匹林（AAVAA）、高压氧治疗（HO）、蛆清创和自体皮肤移植，LLU 愈合。病例 2. 一名 45 岁女性患有 MCTD，活检显示多发性 LLU 伴非特异性炎症。MethP、PR、羟氯喹（HCQ）、硫唑嘌呤（AZA）、CYC、IVIG、AAVAA 治疗失败。治疗基础 LLU 胫骨骨髓炎并加用 CyA 后，LLU 愈合。病例 3. 一名 20 岁男性曾患有结节性多动脉炎（PAN），因小血管血管炎而出现疼痛性 LLU（活检）。MethP、PR 1 mg/kg、CYC、CyA 100 mg/d、AAVAA 治疗失败。耐甲氧西林金黄色葡萄球菌（MRSA）败血症和全身 PAN 复发。给予静脉万古霉素，随后给予环丙沙星、每月静脉注射免疫球蛋白（150g/5 天）和英夫利昔单抗（5mg/kg），LLU 愈合。

结论

LLU 对治疗有极强的抵抗力。需要联合使用多种药物和服务来治疗自身免疫性疾病引起的 LLU。

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Med Sci Monit. 2009 Mar;15(3):CR89-94.
3
Treatment of refractory pyoderma gangrenosum with intravenous immunoglobulin.静脉注射免疫球蛋白治疗难治性坏疽性脓皮病
英夫利昔单抗治疗难治性结节性多动脉炎。
Clin Rheumatol. 2019 Oct;38(10):2825-2833. doi: 10.1007/s10067-019-04474-9. Epub 2019 Apr 10.
4
Intravenous immunoglobulins for treatment of connective tissue diseases in dermatology.静脉注射免疫球蛋白在皮肤科结缔组织疾病治疗中的应用
Wien Med Wochenschr. 2018 Jun;168(9-10):213-217. doi: 10.1007/s10354-017-0595-x. Epub 2017 Sep 1.
5
Connective tissue ulcers.结缔组织溃疡。
J Tissue Viability. 2013 Nov;22(4):92-102. doi: 10.1016/j.jtv.2013.04.003. Epub 2013 Jun 10.
Australas J Dermatol. 2009 Feb;50(1):56-9. doi: 10.1111/j.1440-0960.2008.00506.x.
4
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5
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6
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8
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