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脓毒症的蛋白质组学新进展

Proteomic updates on sepsis.

作者信息

Siqueira-Batista Rodrigo, Mendonça Eduardo Gomes de, Gomes Andréia Patrícia, Vitorino Rodrigo Roger, Miyadahira Renato, Alvarez-Perez Mario Castro, Oliveira Maria Goreti de Almeida

机构信息

Department of Medicine and Nursing and at the Department of Biochemistry and Molecular Biology, Universidade Federal de Viçosa (UFV), Viçosa, MG, Brazil.

出版信息

Rev Assoc Med Bras (1992). 2012 May-Jun;58(3):376-82.

Abstract

The increased knowledge regarding proteomic analysis techniques has allowed for better understanding of the molecular bases related to the identification of cell signaling, modifying protein, and post-translational modification pathways, in addition to the characterization of specific biological markers. Thus, documenting certain proteins expressed in sepsis is a promising approach to elucidate pathophysiological, diagnostic, therapeutic, and prognostic aspects in this condition with a purpose of applying them to clinical practice. Although the studies are still preliminary, proteomics may offer good benefits for the better management of septic patients. Thus, this article aims to introduce a short review of the applications of proteomic studies to sepsis.

摘要

蛋白质组学分析技术知识的增加,有助于更好地理解与细胞信号识别、蛋白质修饰及翻译后修饰途径相关的分子基础,以及特定生物标志物的特征。因此,记录脓毒症中表达的某些蛋白质是一种很有前景的方法,可用于阐明这种病症的病理生理、诊断、治疗和预后方面,以便将其应用于临床实践。尽管这些研究仍处于初步阶段,但蛋白质组学可能为更好地管理脓毒症患者带来诸多益处。因此,本文旨在简要综述蛋白质组学研究在脓毒症中的应用。

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