Damante Giuseppe, Scaloni Andrea, Tell Gianluca
Dipartimento di Scienze e Tecnologie Biomediche, Piazzale Kolbe 1, 33100 Udine, Italy.
Expert Rev Proteomics. 2009 Aug;6(4):363-76. doi: 10.1586/epr.09.51.
Several genomics-based techniques have been applied in the last decade to the molecular characterization of cancer, which has led to a variety of applications suitable for improved diagnosis, prognosis and prediction of outcome to treatment. Proteomics-based approaches have also been seen as crucial to the discovery of biomarkers for early diagnosis and prognosis of tumors, as well as for a better understanding of the molecular bases of cancer. Accordingly, proteomic techniques have been used extensively for a better molecular characterization of thyroid tumors. In this field, three main directions have been preceded: first, proteomic studies of model systems; second, proteomics of thyroid tumor specimens; and third, serum proteomics. In this review, we describe the most relevant results that have been obtained for tumors derived from thyroid follicular cells using various proteomic approaches.
在过去十年中，几种基于基因组学的技术已应用于癌症的分子特征分析，这带来了各种适用于改善癌症诊断、预后和治疗结果预测的应用。基于蛋白质组学的方法也被视为发现肿瘤早期诊断和预后生物标志物以及更好地理解癌症分子基础的关键。因此，蛋白质组学技术已被广泛用于对甲状腺肿瘤进行更好的分子特征分析。在该领域，已出现三个主要方向：第一，模型系统的蛋白质组学研究；第二，甲状腺肿瘤标本的蛋白质组学；第三，血清蛋白质组学。在本综述中，我们描述了使用各种蛋白质组学方法对源自甲状腺滤泡细胞的肿瘤所获得的最相关结果。
