Département de santé environnementale et santé au travail, Chaire d'analyse et de gestion des risques toxicologiques and Institut de recherche en santé publique de l'Université de Montréal (IRSPUM), Faculté de Médecine, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, Québec, Canada H3C 3J7.
Regul Toxicol Pharmacol. 2012 Oct;64(1):161-76. doi: 10.1016/j.yrtph.2012.06.007. Epub 2012 Jun 23.
Impact of prenatal PCB exposure on birth weight was investigated in various children cohorts and findings of published studies show inconsistencies. Because a direct comparison of results obtained from different studies remains difficult, the "biological concentration-birth weight" relationship is not clearly established. The objective of this research was to perform a systematic analysis of published epidemiological data to reassess relationship between prenatal PCB exposure and low birth weight, using toxicokinetic considerations and a novel standardization procedure of biological concentration data across studies. A systematic analysis of 20 epidemiological studies published up to 2011 on this topic was conducted. This was achieved through a standardization of reported exposure data in terms of total PCBs per kg of lipids in maternal plasma. Systematic analysis of the "standardized biological concentration-birth weight" relationship across studies was then conducted through the application of Hill criteria. Combining results of all 20 reviewed studies did not allow to establish an association between prenatal exposure to PCBs at the described levels and abnormal birth weight (<2500g). Our approach provides a framework for the use of published data to establish "PCB biological concentration-response" relationships.
本研究旨在通过应用 Hill 准则，对各研究间的“标准化生物浓度-出生体重”关系进行系统分析，从而重新评估产前 PCB 暴露与低出生体重之间的关系。研究分析了截至 2011 年已发表的 20 项有关这一主题的流行病学研究。通过将母体血浆中总 PCBs 与每公斤脂质的报告暴露数据标准化，实现了这一点。通过应用 Hill 标准，对各研究间的“标准化生物浓度-出生体重”关系进行了系统分析。综合所有 20 项综述研究的结果，无法确定产前接触描述水平的 PCBs 与异常出生体重（<2500g）之间存在关联。我们的方法为利用已发表的数据建立“PCB 生物浓度-反应”关系提供了一个框架。
