McElwee K J, Shapiro J S
Department of Dermatology and Skin Science, The University of British Columbia, Vancouver, BC, Canada.
Skin Therapy Lett. 2012 Jun;17(6):1-4.
Androgenetic alopecia (AGA) may affect up to 70% of men and 40% of women at some point in their lifetime. While men typically present with a distinctive alopecia pattern involving hairline recession and vertex balding, women normally exhibit a diffuse hair thinning over the top of their scalps. The treatment standard in dermatology clinics continues to be minoxidil and finasteride with hair transplantation as a surgical option. Here we briefly review current therapeutic options and treatments under active investigation. Dutasteride and ketoconazole are also employed for AGA, while prostaglandin analogues latanoprost and bimatoprost are being investigated for their hair growth promoting potential. Laser treatment products available for home use and from cosmetic clinics are becoming popular. In the future, new cell mediated treatment approaches may be available for AGA. While there are a number of potential treatment options, good clinical trial data proving hair growth efficacy is limited.
雄激素性脱发（AGA）在一生中的某些时候可能会影响高达70%的男性和40%的女性。男性通常表现出一种独特的脱发模式，包括发际线后移和头顶秃发，而女性通常表现为头皮顶部弥漫性头发变薄。皮肤科诊所的治疗标准仍然是米诺地尔和非那雄胺，植发则作为一种手术选择。在此，我们简要回顾当前的治疗选择以及正在积极研究的治疗方法。度他雄胺和酮康唑也用于AGA的治疗，而前列腺素类似物拉坦前列素和比马前列素因其促进头发生长的潜力正在接受研究。可从家用和美容诊所获得的激光治疗产品正变得越来越受欢迎。未来，可能会有新的细胞介导治疗方法用于AGA。虽然有许多潜在的治疗选择，但证明头发生长疗效的良好临床试验数据有限。
