King's College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, Research Oncology, 3rd Floor, Bermondsey Wing London, Guy's Hospital, London SE1 9RT, UK.
Br J Cancer. 2012 Jul 10;107(2):221-3. doi: 10.1038/bjc.2012.273. Epub 2012 Jun 26.
The understanding of metastatic patterns after metachronous contralateral breast cancer (CBC) may help determine the biological nature of CBC.
A cohort of 8478 women with breast cancer treated at Guy's and St Thomas' NHS Foundation Trust between 1975 and 2006 were studied. Organ-specific 5-year cumulative incidence and incidence rate ratios were assessed for women diagnosed with unilateral breast cancer (UBC), CBC within 5 years and CBC more than 5 years of the initial diagnosis.
Women diagnosed with CBC within 5 years had a higher incidence of metastases in all organs compared with UBC. Women with a short interval time to CBC developed metastasis more rapidly and were more likely to develop visceral and distant cutaneous metastases compared with bone metastasis.
These findings explain poor prognosis of women with early occurring CBC and suggest that some of these CBCs are indicators of aggressive and/or systemic disease.
对异时性对侧乳腺癌（CBC）转移模式的理解有助于确定 CBC 的生物学性质。
研究了 1975 年至 2006 年间在盖伊和圣托马斯国民保健信托基金会接受治疗的 8478 名乳腺癌女性患者。评估了单侧乳腺癌（UBC）、5 年内诊断为 CBC 以及初始诊断后 5 年以上诊断为 CBC 的女性的器官特异性 5 年累积发生率和发病率比值。
与 UBC 相比，5 年内诊断为 CBC 的女性所有器官的转移发生率更高。与骨转移相比，CBC 间隔时间较短的女性转移更快，更有可能发生内脏和远处皮肤转移，而不是骨转移。
这些发现解释了早期发生的 CBC 女性预后不良的原因，并表明其中一些 CBC 是侵袭性和/或全身性疾病的指标。
