Sathya M, Kokilavani R, Teepa K S Ananta, Balakrishnan A
Department of Biochemistry, Kongunadu Arts and Science College, Coimbatore, India.
Anc Sci Life. 2011 Jul;31(1):3-9.
The ethanolic extract of Acalypha indica was tested for its biopotency on membrane bound enzymes and marker enzymes in urolithiasis in male wistar albino rats. Calcium oxalate urolithiasis was induced by 0.75% ethylene glycol in drinking water for 30 days. There was a significant decrease in membrane bound enzymes such as Ca(2+) ATPase, Mg(2+) ATPase, Na(+)K(+) ATPase and marker enzymes Aspartate Transaminase (AST), Alanine Transaminase (ALT), Acid phosphatase (ACP) and Alkaline Phosphatase (ALP) in liver and kidney. The AST, ALT, ACP and ALP were increased in serum and urine of rats. Therapeutic treatment with plant extract (200mg/kg b.wt.dose(-1) day(-1) oral(-1)) has significantly ameliorated to near normalcy in the curative group. These results of the present study concluded that A. indica can play an important role in the prevention of disorders associated with kidney stone formation.
对印度铁苋菜的乙醇提取物进行了测试，以研究其对雄性Wistar白化大鼠尿路结石中膜结合酶和标记酶的生物活性。通过在饮用水中添加0.75%的乙二醇诱导草酸钙尿路结石30天。肝脏和肾脏中膜结合酶如Ca(2+)ATP酶、Mg(2+)ATP酶、Na(+)K(+)ATP酶以及标记酶天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、酸性磷酸酶（ACP）和碱性磷酸酶（ALP）显著降低。大鼠血清和尿液中的AST、ALT、ACP和ALP升高。用植物提取物（200mg/kg体重剂量(-1)天(-1)口服(-1)）进行治疗，治疗组的各项指标显著改善至接近正常水平。本研究结果表明，印度铁苋菜在预防与肾结石形成相关的疾病方面可发挥重要作用。
