脑室内注射胍丁胺对大鼠水迷宫学习记忆的影响
The Effect of Intra-CA1 Agmatine Microinjection on Water Maze Learning and Memory in Rat.
作者信息
Rastegar K, Roosta H, Zarifkar A, Rafati A, Moosavi M
机构信息
Shiraz Neuroscience Research Center and Department of Physiology, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Iran Red Crescent Med J. 2011 May;13(5):316-22. Epub 2011 May 1.
BACKGROUND
Reports on agmatine are controversial showing that it may improve memory, it can deteriorate memory and some did not notice any interference with learning and memory. In the present study, the effect of directly intra-CA1 agmatine microinjection on water maze learning and memory has been assessed.
METHODS
The cannuls were implanted in hippocampal CA1 regions of rats in a sterotaxic frame after general anesthesia. After one week recovery period, the animals were assessed in the reference memory version of water maze. Agmatine (1, 10, 100 or 200 μg/0.5 μl) or saline were infused 20 minutes before or immediately after training.
RESULTS
Agmatine-treated rats did not show any significant difference neither in water maze acquisition nor in consolidation task in comparison with control and sham groups.
CONCLUSION
Agmatine does not affect water maze learning and memory.
背景
关于胍丁胺的报道存在争议，有研究表明它可能改善记忆，也有研究显示它会损害记忆，还有一些研究未发现其对学习和记忆有任何干扰。在本研究中，评估了直接向CA1区微量注射胍丁胺对水迷宫学习和记忆的影响。
方法
在全身麻醉下，将套管植入大鼠海马CA1区的立体定位框架中。经过一周的恢复期后，在水迷宫的参考记忆版本中对动物进行评估。在训练前20分钟或训练后立即注入胍丁胺（1、10、100或200μg/0.5μl）或生理盐水。
结果
与对照组和假手术组相比，接受胍丁胺治疗的大鼠在水迷宫获取和巩固任务中均未显示出任何显著差异。
结论
胍丁胺不影响水迷宫学习和记忆。
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