Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Diabetes Metab J. 2012 Jun;36(3):167-80. doi: 10.4093/dmj.2012.36.3.167. Epub 2012 Jun 14.
Retinoid acid is a metabolite of vitamin A and functions as an important factor in cell survival, differentiation and death. Most previous studies on retinoid metabolism have focused on its association with cancer, hematologic and dermatologic disorders. Given the special concern over the recent increase in the prevalence of diabetes worldwide, the role of retinoid metabolism on glucose metabolism and insulin resistance in the human body is of marked importance. Therefore, in this issue, we review the literature on the association of retinoid metabolism with glucose tolerance, with regard to insulin secretion, pancreatic autoimmunity, insulin sensitivity and lipid metabolism. Further, we tried to assess the possibility of using retinoids as a novel therapeutic strategy for diabetes.
视黄酸是维生素 A 的代谢产物，作为细胞存活、分化和死亡的重要因素发挥作用。大多数关于视黄酸代谢的先前研究都集中在其与癌症、血液和皮肤疾病的关联上。鉴于最近全球糖尿病患病率的上升引起了人们的特别关注，视黄酸代谢在人体葡萄糖代谢和胰岛素抵抗中的作用具有重要意义。因此，在本期中，我们回顾了有关视黄酸代谢与葡萄糖耐量、胰岛素分泌、胰腺自身免疫、胰岛素敏感性和脂代谢关系的文献。此外，我们还试图评估将视黄酸用作糖尿病新的治疗策略的可能性。
