Department of Biotechnology and Life Science, Faculty of Technology, Tokyo University of Agriculture and Technology, 2-24-26 Naka-cho, Koganei, Tokyo, Japan.
Chem Commun (Camb). 2012 Aug 14;48(63):7777-89. doi: 10.1039/c2cc31846f. Epub 2012 Jun 26.
This review describes recent advances by our research group in the design and applications of conformationally flexible guanidine/bisthiourea organocatalysts to facilitate unique bond-forming processes, including retro-free, enantiodivergent, entropy-controlled, and cycle-specific organocatalysis. Special emphasis is placed on the key requirements to attain high selectivity and on functional switching by exploiting the structural flexibility of our organocatalysts.
本文综述了我们研究小组在设计和应用构象柔性胍/双硫脲有机催化剂方面的最新进展，这些催化剂可促进独特的成键过程，包括反自由、对映异构发散、熵控制和循环特异性的有机催化。特别强调了通过利用我们的有机催化剂的结构灵活性来实现高选择性和功能切换的关键要求。
