Murphy Melissa L, Frodl Thomas
Department of Psychiatry and Institute of Neuroscience, School of Medicine, Trinity College Dublin, University of Dublin, College Green, Dublin 2, Ireland.
Biol Mood Anxiety Disord. 2011 Sep 27;1(1):3. doi: 10.1186/2045-5380-1-3.
Fractional anisotropy anomalies occurring in the white matter tracts in the brains of depressed patients may reflect microstructural changes underlying the pathophysiology of this disorder. We conducted a meta-analysis of fractional anisotropy abnormalities occurring in major depressive disorder using voxel-based diffusion tensor imaging studies. Using the Embase, PubMed and Google Scholar databases, 89 relevant data sets were identified, of which 7 (including 188 patients with major depressive disorder and 221 healthy controls) met our inclusion criteria. Authors were contacted to retrieve any additional data required. Coordinates were extracted from clusters of significant white matter fractional anisotropy differences between patients and controls. Relevant demographic, clinical and methodological variables were extracted from each study or obtained directly from authors. The meta-analysis was carried out using Signed Differential Mapping. Patients with depression showed decreased white matter fractional anisotropy values in the superior longitudinal fasciculus and increased fractional anisotropy values in the fronto-occipital fasciculus compared to controls. Using quartile and jackknife sensitivity analysis, we found that reduced fractional anisotropy in the left superior longitudinal fasciculus was very stable, with increases in the right fronto-occipital fasciculus driven by just one study. In conclusion, our meta-analysis revealed a significant reduction in fractional anisotropy values in the left superior longitudinal fasciculus, which may ultimately play an important role in the pathology of depression.
抑郁症患者大脑白质纤维束中出现的各向异性分数异常可能反映了该疾病病理生理学背后的微观结构变化。我们使用基于体素的扩散张量成像研究对重度抑郁症中出现的各向异性分数异常进行了荟萃分析。通过Embase、PubMed和谷歌学术数据库，我们识别出89个相关数据集，其中7个（包括188例重度抑郁症患者和221名健康对照）符合我们的纳入标准。我们联系了作者以获取所需的任何额外数据。从患者与对照之间显著的白质各向异性分数差异簇中提取坐标。从每项研究中提取或直接从作者处获得相关的人口统计学、临床和方法学变量。使用符号差分映射进行荟萃分析。与对照组相比，抑郁症患者在左上纵束中的白质各向异性分数值降低，而在额枕束中的各向异性分数值升高。通过四分位数和留一法敏感性分析，我们发现左上纵束中各向异性分数的降低非常稳定，而右额枕束中的升高仅由一项研究驱动。总之，我们的荟萃分析显示左上纵束中的各向异性分数值显著降低，这可能最终在抑郁症的病理学中发挥重要作用。
