首发单相重性抑郁障碍未用药患者的脑白质异常。
Whiter matter abnormalities in medication-naive subjects with a single short-duration episode of major depressive disorder.
机构信息
Department of Psychiatry, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China.
出版信息
Psychiatry Res. 2011 Jan 30;191(1):80-3. doi: 10.1016/j.pscychresns.2010.09.002. Epub 2010 Dec 10.
Abstract
Convergent studies have implicated white matter abnormalities in the pathophysiology of major depressive disorder (MDD). In this study, diffusion tensor imaging (DTI) was used to examine white matter abnormalities in 23 single-episode, medication-naive MDD participants versus 21 healthy control participants. Voxel-based analysis was used to investigate whole brain white matter abnormalities in the MDD group. Fractional anisotropy was significantly lower and apparent diffusion coefficient was significantly higher in the right superior longitudinal fasciculus (SLF) within the frontal lobe, right middle frontal and left parietal white matter in the MDD group compared with the healthy group.
摘要
多项研究表明，在重度抑郁症（MDD）的病理生理学中存在白质异常。在这项研究中，采用弥散张量成像（DTI）技术对 23 例首发、未经药物治疗的 MDD 患者和 21 名健康对照者的白质异常进行了检查。基于体素的分析方法用于研究 MDD 组的全脑白质异常。与健康组相比，MDD 组右侧额上额束（SLF）、右侧额中回和左侧顶叶白质的各向异性分数显著降低，表观弥散系数显著升高。
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