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剖腹手术期间腹腔内分泌的趋化因子和细胞因子的综合分析。

Comprehensive analysis of chemokines and cytokines secreted in the peritoneal cavity during laparotomy.

作者信息

Kawashima Rei, Kawamura Yuki I, Oshio Tomoyuki, Mizutani Noriko, Okada Toshihiko, Kawamura Yutaka J, Konishi Fumio, Dohi Taeko

机构信息

Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.

出版信息

J Immunoassay Immunochem. 2012;33(3):291-301. doi: 10.1080/15321819.2011.638409.

DOI:10.1080/15321819.2011.638409
PMID:22738652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3431549/
Abstract

We recently found that chemokine-driven peritoneal cell aggregation is the primary mechanism of postoperative adhesion in a mouse model. To investigate this in humans, paired samples of peritoneal lavage fluid were obtained from seven patients immediately after incision (preoperative) and before closure (postoperative), and were assayed for the presence of 27 cytokines and chemokines using multiplex beads assay. As a result, IL-6 and CCL5 showed the most striking increase during operation. Recombinant CCL5 or lavage fluid induced chemotaxis of human peripheral blood mononuclear cells. We propose that CCL5 is possibly involved in the mechanism of postoperative adhesion in humans.

摘要

我们最近发现，趋化因子驱动的腹膜细胞聚集是小鼠模型中术后粘连的主要机制。为了在人类中研究这一现象，我们从7名患者身上在切开后立即（术前）和缝合前（术后）获取了配对的腹腔灌洗液样本，并使用多重微珠分析法检测了27种细胞因子和趋化因子的存在情况。结果显示，IL-6和CCL5在手术过程中出现了最显著的增加。重组CCL5或灌洗液可诱导人外周血单核细胞的趋化作用。我们认为CCL5可能参与了人类术后粘连的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c1/3431549/493e3e5492b0/ljii33_291_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c1/3431549/c7803517622e/ljii33_291_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c1/3431549/78aac9018b2b/ljii33_291_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c1/3431549/493e3e5492b0/ljii33_291_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c1/3431549/c7803517622e/ljii33_291_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c1/3431549/78aac9018b2b/ljii33_291_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73c1/3431549/493e3e5492b0/ljii33_291_f3.jpg

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本文引用的文献

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J Immunol. 2009 Apr 1;182(7):3945-6. doi: 10.4049/jimmunol.0990015.
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3
Functional Th1 cells are required for surgical adhesion formation in a murine model.在小鼠模型中，功能性Th1细胞是手术粘连形成所必需的。
趋化因子受体CCR8是小鼠腹腔巨噬细胞中脂多糖触发的细胞因子产生所必需的。
PLoS One. 2014 Apr 8;9(4):e94445. doi: 10.1371/journal.pone.0094445. eCollection 2014.
J Immunol. 2008 May 15;180(10):6970-6976. doi: 10.4049/jimmunol.180.10.6970.
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Interferon-gamma is a therapeutic target molecule for prevention of postoperative adhesion formation.γ干扰素是预防术后粘连形成的治疗靶点分子。
Nat Med. 2008 Apr;14(4):437-41. doi: 10.1038/nm1733. Epub 2008 Mar 16.
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Human peritoneal macrophages show functional characteristics of M-CSF-driven anti-inflammatory type 2 macrophages.人腹膜巨噬细胞表现出M-CSF驱动的抗炎性2型巨噬细胞的功能特征。
Eur J Immunol. 2007 Jun;37(6):1594-9. doi: 10.1002/eji.200737042.
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Inhibition of CCL1-CCR8 interaction prevents aggregation of macrophages and development of peritoneal adhesions.抑制CCL1与CCR8的相互作用可防止巨噬细胞聚集和腹膜粘连的形成。
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