Mantovani Alberto, Sica Antonio, Locati Massimo
Istituto Clinico Humanitas, and Institute of General Pathology, University of Milan, Milan, Italy.
Immunity. 2005 Oct;23(4):344-6. doi: 10.1016/j.immuni.2005.10.001.
Functional polarization of macrophages into M1 or M2 cells is an operationally useful, simplified conceptual framework describing the plasticity of mononuclear phagocytes. Genetic approaches have begun to shed new light on mechanisms underlying macrophage polarization and on the actual in vivo significance of polarized M2 cells ( [this issue of Immunity]).
巨噬细胞向M1或M2细胞的功能极化是一个在操作上有用的、简化的概念框架，用于描述单核吞噬细胞的可塑性。遗传学方法已开始为巨噬细胞极化的潜在机制以及极化M2细胞在体内的实际意义带来新的启示（《免疫》本期）。
