Conde Délio Marques, Costa-Paiva Lúcia, Martinez Edson Zangiacomi, Mendes Pinto-Neto Aarão
Breast Service, Hospital for Maternal and Child Healthcare, Goiânia, Ribeirão Preto, Brazil.
Breast Care (Basel). 2012 Apr;7(2):121-125. doi: 10.1159/000337763. Epub 2012 Apr 23.
The aim of this study was to investigate the prevalence of low bone mineral density (BMD) and associated factors in middle-aged breast cancer survivors (BCS). PATIENTS AND METHODS: A cross-sectional study was conducted with 70 BCS of 45-65 years of age undergoing complete oncology treatment. Logistic regression models were used to identify factors associated with low BMD (osteopenia and osteoporosis taken together as a single group). RESULTS: The mean age of participants was 53.2 ± 5.9 years. BMD was low at the femoral neck in 28.6% of patients and at the lumbar spine in 45.7%. Body mass index ≤ 30 kg/m(2) (adjusted odds ratio (OR) 3.43; 95% confidence interval (CI) 1.0-11.3) and postmenopausal status (OR adjusted 20.42; 95% CI 2.0-201.2) were associated with low BMD at the lumbar spine. Femoral neck measurements, age > 50 years (OR 3.41; 95% CI 1.0-11.6), and time since diagnosis > 50 months (OR adjusted 3.34; 95% CI 1.0-11.3) increased the likelihood of low BMD. CONCLUSION: These findings show that low BMD is common in middle-aged BCS. Factors were identified that may affect BMD in BCS and should be considered when implementing strategies to minimize bone loss in middle-aged women with breast cancer.
本研究旨在调查中年乳腺癌幸存者（BCS）中低骨密度（BMD）的患病率及相关因素。
对70名年龄在45 - 65岁且已完成肿瘤治疗的BCS进行了一项横断面研究。采用逻辑回归模型来确定与低骨密度（将骨质减少和骨质疏松合并为一组）相关的因素。
参与者的平均年龄为53.2±5.9岁。28.6%的患者股骨颈骨密度低，45.7%的患者腰椎骨密度低。体重指数≤30kg/m²（调整后的优势比（OR）为3.43；95%置信区间（CI）为1.0 - 11.3）和绝经后状态（调整后的OR为20.42；95%CI为2.0 - 201.2）与腰椎低骨密度相关。股骨颈测量值、年龄>50岁（OR为3.41；95%CI为1.0 - 11.6）以及诊断后时间>50个月（调整后的OR为3.34；95%CI为1.0 - 11.3）增加了低骨密度的可能性。
这些发现表明低骨密度在中年BCS中很常见。已确定了可能影响BCS骨密度的因素，在实施策略以尽量减少中年乳腺癌女性骨质流失时应予以考虑。
