8-羟基-2'-脱氧鸟苷的表达可预测肝细胞癌的预后。
8-Hydroxy-2'-deoxyguanosine expression predicts hepatocellular carcinoma outcome.
作者信息
Li Shengmian, Wang Xiaoling, Wu Yijuan, Zhang Huijing, Zhang Lan, Wang Cuiju, Zhang Ruixing, Guo Zhanjun
机构信息
Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.
出版信息
Oncol Lett. 2012 Feb;3(2):338-342. doi: 10.3892/ol.2011.477. Epub 2011 Nov 10.
Abstract
Hepatocellular carcinoma (HCC) is characterized by increased oxidative stress and the production of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which is one of the main mutagenic modifications of DNA by oxidative stress. We analyzed the association of 8-OHdG with post-operative survival and revealed that low levels of 8-OHdG are associated with significantly shorter survival time. Moreover, levels of 8-OHdG were associated with HCC characteristics, including tumor size, tumor quantity, clinical staging, Child classification, portal vein thrombosis and ascites. These results suggest that oxidative damage is a useful prognostic marker in HCC when other clinical characteristics are present with 8-OHdG.
摘要
肝细胞癌（HCC）的特征是氧化应激增加以及8-羟基-2'-脱氧鸟苷（8-OHdG）的产生，8-OHdG是氧化应激导致DNA主要诱变修饰之一。我们分析了8-OHdG与术后生存率的关联，发现低水平的8-OHdG与显著缩短的生存时间相关。此外，8-OHdG水平与HCC特征相关，包括肿瘤大小、肿瘤数量、临床分期、Child分级、门静脉血栓形成和腹水。这些结果表明，当8-OHdG与其他临床特征同时存在时，氧化损伤是HCC中一个有用的预后标志物。
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