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Identification of sequence polymorphisms in the displacement loop region of mitochondrial DNA as a risk factor for renal cell carcinoma.线粒体DNA置换环区域序列多态性作为肾细胞癌危险因素的鉴定。
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Single nucleotide polymorphisms in the mitochondrial displacement loop and age at onset of non-Hodgkin lymphoma.线粒体置换环中单核苷酸多态性与非霍奇金淋巴瘤发病年龄的关系。
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本文引用的文献

1
Sequence polymorphisms of mitochondrial D-loop and hepatocellular carcinoma outcome.线粒体 D-环序列多态性与肝细胞癌预后。
Biochem Biophys Res Commun. 2011 Mar 18;406(3):493-6. doi: 10.1016/j.bbrc.2011.02.088. Epub 2011 Feb 21.
2
Single nucleotide polymorphisms in the mitochondrial displacement loop and outcome of esophageal squamous cell carcinoma.线粒体置换环中单核苷酸多态性与食管鳞癌预后的关系。
J Exp Clin Cancer Res. 2010 Nov 26;29(1):155. doi: 10.1186/1756-9966-29-155.
3
Identification of sequence polymorphism in the D-Loop region of mitochondrial DNA as a risk factor for hepatocellular carcinoma with distinct etiology.鉴定线粒体 DNA D 环区序列多态性作为具有不同病因的肝细胞癌的危险因素。
J Exp Clin Cancer Res. 2010 Sep 18;29(1):130. doi: 10.1186/1756-9966-29-130.
4
Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis.关于饮酒和吸烟对年轻食管癌鳞状细胞癌诊断的ADH1B和ALDH2基因多态性的遗传调控。
Int J Cancer. 2009 Sep 1;125(5):1134-42. doi: 10.1002/ijc.24357.
5
[Prognostic and predictive factors of oesophageal carcinoma].[食管癌的预后和预测因素]
Bull Cancer. 2009 Apr;96(4):379-89. doi: 10.1684/bdc.2008.0778.
6
Polymorphisms in mitochondrial genes and prostate cancer risk.线粒体基因多态性与前列腺癌风险
Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3558-66. doi: 10.1158/1055-9965.EPI-08-0434.
7
Mitochondrial genetic polymorphisms and pancreatic cancer risk.线粒体基因多态性与胰腺癌风险
Cancer Epidemiol Biomarkers Prev. 2007 Jul;16(7):1455-9. doi: 10.1158/1055-9965.EPI-07-0119.
8
Mitochondrial genetic background modifies breast cancer risk.线粒体遗传背景会改变乳腺癌风险。
Cancer Res. 2007 May 15;67(10):4687-94. doi: 10.1158/0008-5472.CAN-06-3554.
9
Nuclear HMGA1 nonhistone chromatin proteins directly influence mitochondrial transcription, maintenance, and function.核内高迁移率族蛋白A1（HMGA1）非组蛋白染色质蛋白直接影响线粒体转录、维持及功能。
Exp Cell Res. 2007 Jan 1;313(1):77-87. doi: 10.1016/j.yexcr.2006.09.014. Epub 2006 Sep 22.
10
Mitochondrial DNA D-loop in pancreatic cancer: somatic mutations are epiphenomena while the germline 16519 T variant worsens metabolism and outcome.胰腺癌中的线粒体DNA D环区：体细胞突变是附带现象，而种系16519 T变异会使代谢及预后恶化。
Am J Clin Pathol. 2006 Oct;126(4):593-601. doi: 10.1309/GQFCCJMH5KHNVX73.

线粒体置换环中的单核苷酸多态性与食管鳞状细胞癌的发病年龄

Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of esophageal squamous cell carcinoma.

作者信息

Guo Zhanjun, Yang Hua, Zhang Fengbin, Zhang Ruixing, Wang Cuiju

机构信息

Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, P.R. China.

出版信息

Oncol Lett. 2012 Feb;3(2):482-484. doi: 10.3892/ol.2011.494. Epub 2011 Nov 25.

DOI:10.3892/ol.2011.494
PMID:22740936
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3362473/
Abstract

The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described for various types of cancer, and their association with cancer risk and disease outcome has been extensively identified. In the present study, we investigated the association between age-at-onset and SNPs in the mitochondrial D-loop using a population-based series of esophageal squamous cell carcinoma (ESCC) patients. The SNP sites of nucleotides 16266 C/T were identified for their association with age-at-onset using the log-rank test. The age-at-onset of patients with the minor allele T genotype was significantly lower than that of patients with the C genotype at the 16266 site (p=0.036). Genetic polymorphisms in the D-loop are predictive markers for age-at-onset in ESCC patients. Accordingly, the analysis of genetic polymorphisms in the mitochondrial D-loop may help identify ESCC patient subgroups at high risk of early onset.

摘要

线粒体DNA（mtDNA）置换环（D-loop）中单个核苷酸多态性（SNP）的积累已在多种类型的癌症中被描述，并且它们与癌症风险和疾病预后的关联也已被广泛确定。在本研究中，我们使用基于人群的一系列食管鳞状细胞癌（ESCC）患者，研究了线粒体D-loop中SNP与发病年龄之间的关联。使用对数秩检验确定核苷酸16266 C/T的SNP位点与发病年龄的关联。在16266位点，携带次要等位基因T基因型患者的发病年龄显著低于携带C基因型的患者（p = 0.036）。D-loop中的基因多态性是ESCC患者发病年龄的预测标志物。因此，分析线粒体D-loop中的基因多态性可能有助于识别早发风险高的ESCC患者亚组。