紫外线B照射对小鼠表皮中微小RNA表达的影响。
Effect of UVB irradiation on microRNA expression in mouse epidermis.
作者信息
Zhou Bing-Rong, Xu Yang, Luo Dan
机构信息
Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. China.
出版信息
Oncol Lett. 2012 Mar;3(3):560-564. doi: 10.3892/ol.2012.551. Epub 2012 Jan 3.
Abstract
The aim of this study was to assess the effects of UVB irradiation on miRNA expression in the mouse epidermis. We determined miRNA expression profiles in the epidermis of UVB irradiated mice and untreated mice, and conducted TargetScan and Gene Ontology analyses to predict miRNA targets. Three miRNAs were downregulated and three were upregulated in the epidermis of UVB irradiated mice compared with untreated mice, and were predicted to be associated with photocarcinogenesis, hypomethylation and apoptosis. miRNAs are potentially involved in the pathogenesis of photodamage, and may aid in the treatment and prevention of UVB-induced dermatoses.
摘要
本研究的目的是评估紫外线B（UVB）照射对小鼠表皮中微小RNA（miRNA）表达的影响。我们测定了UVB照射小鼠和未处理小鼠表皮中的miRNA表达谱，并进行了TargetScan和基因本体分析以预测miRNA的靶标。与未处理小鼠相比，UVB照射小鼠表皮中有三种miRNA表达下调，三种miRNA表达上调，且预计它们与光致癌作用、低甲基化和细胞凋亡有关。miRNA可能参与了光损伤的发病机制，并可能有助于UVB诱导的皮肤病的治疗和预防。
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