Xia Li, Xue Xiu-Zhen
The First Affiliated Hospital of Henan Scientific and Technological University, Henan, Luoyang 471003, P.R. China.
Oncol Lett. 2012 Apr 1;3(4):839-844. doi: 10.3892/ol.2012.564. Epub 2012 Jan 12.
The present study aimed to evaluate the expression of NF-κB p65, c-IAP2 and caspase-3 in human cervical cancer. Immunohistochemistry was performed to determine the levels of NF-κB p65, c-IAP2 and caspase-3 expression in cervical cancer. Our study found overexpression of NF-κB p65 and c-IAP2 and reduced expression of caspase-3 in cervical cancer and cervical intraepithelial neoplasia (CIN) II-III. The expression of these molecules had no significant differences in the various clinical stages of cervical cancer, but the expression levels of NF-κB p65 and c-IAP2 in poorly differentiated tumors and metastatic lymph nodes were higher than levels in well-differentiated tumors and non-metastatic lymph nodes. By contrast, caspase-3 expression in well-differentiated tumors and non-metastatic lymph nodes was higher than that in poorly differentiated tumors and metastatic lymph nodes. Overexpression of NF-κB p65 and c-IAP2 and reduced expression of caspase-3 in cervical cancer may be important in the tumorigenesis and development of cervical cancer, and they may be useful as biomarkers to estimate progression of cervical cancer.
本研究旨在评估NF-κB p65、c-IAP2和caspase-3在人类宫颈癌中的表达情况。采用免疫组织化学方法检测宫颈癌中NF-κB p65、c-IAP2和caspase-3的表达水平。我们的研究发现，在宫颈癌和宫颈上皮内瘤变（CIN）II-III中，NF-κB p65和c-IAP2表达上调，而caspase-3表达下调。这些分子的表达在宫颈癌的不同临床分期中无显著差异，但在低分化肿瘤和转移淋巴结中，NF-κB p65和c-IAP2的表达水平高于高分化肿瘤和非转移淋巴结。相反，高分化肿瘤和非转移淋巴结中caspase-3的表达高于低分化肿瘤和转移淋巴结。宫颈癌中NF-κB p65和c-IAP2的过表达以及caspase-3的低表达可能在宫颈癌的发生发展中起重要作用，它们可能作为评估宫颈癌进展的生物标志物。
