Dipartimento di Patologia Sperimentale, Università di Bologna, Italy.
Toxins (Basel). 2012 Mar;4(3):157-90. doi: 10.3390/toxins4030157. Epub 2012 Mar 1.
Shiga toxins and ricin are well characterized similar toxins belonging to quite different biological kingdoms. Plant and bacteria have evolved the ability to produce these powerful toxins in parallel, while humans have evolved a defense system that recognizes molecular patterns common to foreign molecules through specific receptors expressed on the surface of the main actors of innate immunity, namely monocytes and neutrophils. The interactions between these toxins and neutrophils have been widely described and have stimulated intense debate. This paper is aimed at reviewing the topic, focusing particularly on implications for the pathogenesis and diagnosis of hemolytic uremic syndrome.
志贺毒素和蓖麻毒素是两种特征明显的相似毒素，它们分属于截然不同的生物界。植物和细菌都进化出了平行产生这些强大毒素的能力，而人类则进化出了一种防御系统，通过先天免疫主要参与者（即单核细胞和中性粒细胞）表面表达的特定受体，识别常见于外来分子的分子模式。这些毒素与中性粒细胞之间的相互作用已被广泛描述，并引发了激烈的争论。本文旨在回顾这一主题，特别关注其对溶血性尿毒症综合征发病机制和诊断的影响。
