Nitsch R, Bergmann I, Küppers K, Mueller G, Frotscher M
Institute of Anatomy, University of Freiburg, F.R.G.
Neurosci Lett. 1990 Oct 16;118(2):147-50. doi: 10.1016/0304-3940(90)90613-e.
The calcium-binding protein parvalbumin (PARV) is supposed to have a protective function under conditions of experimental seizure and hypoxia in a subgroup of GABAergic inhibitory neurons in the adult rat hippocampus. Here we studied the appearance of PARV immunoreactivity in rat hippocampal non-pyramidal cells during postnatal development in comparison to glutamate decarboxylase (GAD) immunoreactivity. PARV-immunoreactive neurons were not observed before postnatal day 7 whereas GAD-positive neurons and terminal-like puncta were present at postnatal day 2 (P2) and were frequent around P5. From other studies it is known that all GABAergic neurons are formed prenatally. Our data thus indicate that in the early postnatal period GABAergic non-pyramidal cells are poorly protected by calcium-binding proteins against a pathological calcium influx.
钙结合蛋白小白蛋白（PARV）被认为在成年大鼠海马体中一组γ-氨基丁酸（GABA）能抑制性神经元的实验性癫痫发作和缺氧条件下具有保护作用。在此，我们研究了出生后发育过程中大鼠海马体非锥体细胞中小白蛋白免疫反应性的出现情况，并与谷氨酸脱羧酶（GAD）免疫反应性进行了比较。出生后第7天之前未观察到PARV免疫反应性神经元，而GAD阳性神经元和终末样小点在出生后第2天（P2）就已存在，且在P5左右较为常见。从其他研究中可知，所有GABA能神经元都是在出生前形成的。因此，我们的数据表明，在出生后的早期阶段，GABA能非锥体细胞受钙结合蛋白保护以抵御病理性钙内流的能力较弱。
