Dias Catarina, Martins Jorge, Dias Graça, Faria Teresa, Brazão Luz Reis
Autoimmune Diseases Unit, Department of Internal Medicine, Central Hospital in Funchal, Funchal, Madeira Island 9054-535, Portugal.
Discov Med. 2012 Jun;13(73):417-24.
Patients with autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and Sjögren's syndrome have an increased risk of developing B-cell non-Hodgkin's lymphomas but the mechanisms behind this phenomenon remain unknown. By focusing on recent research reports we explore and discuss some of the proposed mechanisms that contribute to this link. The complexity is enormous and can involve genetic and environmental factors, chronic immune stimulation by antigens, and even the treatment for these autoimmune diseases. These mechanisms can be combined in different ways causing great variability in one's predisposition to lymphomagenesis. Knowing more about these pathways is urgent. The more we know about autoimmune diseases the better we can treat our patients effectively and the more we can prevent lymphomas from developing.
患有自身免疫性疾病（如系统性红斑狼疮、类风湿性关节炎和干燥综合征）的患者发生B细胞非霍奇金淋巴瘤的风险增加，但这一现象背后的机制仍不清楚。通过关注近期的研究报告，我们探索并讨论了一些可能导致这种关联的机制。其复杂性极大，可能涉及遗传和环境因素、抗原引起的慢性免疫刺激，甚至这些自身免疫性疾病的治疗。这些机制可以以不同方式组合，导致个体发生淋巴瘤的易感性差异很大。迫切需要更多地了解这些途径。我们对自身免疫性疾病了解得越多，就越能有效地治疗患者，也越能预防淋巴瘤的发生。
