Laboratory of Nanoradiopharmaceuticals, Nuclear Engineering Institute, Brazil.
J Pharm Biomed Anal. 2012 Nov;70:602-4. doi: 10.1016/j.jpba.2012.06.008. Epub 2012 Jun 13.
Nanotechnology is attracting increasing attention worldwide. This study was made use of modern technology to decipher most of the intriguing biological aspects of nanoparticles. Labeling with technetium-99m ((99m)Tc) of six nanoparticles using different compositions and formulations, as well as complete biodistribution studies in mice was done. The results showed that the behaviors of nanoparticles were very different from each other. Mesoporous silica showed a high affinity for lung tissue, whereas polymeric nanoparticles were rapidly recognized and metabolized by the liver. The six nanoparticles showed different renal clearance times, suggesting that their area mechanisms of action were related to interaction and solubility. The labeling process in all samples showed similar results (all >99%). Biodistribution was demonstrated to be important for the study of nanoparticles, and could be used to predict the possible mechanism of action of nanoparticles.
纳米技术在全球范围内受到越来越多的关注。本研究利用现代技术来揭示纳米粒子最有趣的生物学方面。使用不同的组成和配方对 6 种纳米粒子进行锝-99m（99mTc）标记，并在小鼠中进行完整的生物分布研究。结果表明，纳米粒子的行为差异很大。介孔硅对肺组织具有高亲和力，而聚合物纳米粒子则被肝脏迅速识别和代谢。6 种纳米粒子显示出不同的肾清除时间，表明它们的作用机制与相互作用和溶解度有关。所有样品的标记过程均显示出相似的结果（均>99%）。生物分布对于纳米粒子的研究非常重要，并可用于预测纳米粒子可能的作用机制。
