Department of Trauma Surgery, The Catholic University of Korea, Uijeongbu St. Mary's Hospital, Uijeongbu-si, Gyeonggi-do, Republic of Korea.
Am J Emerg Med. 2013 Jan;31(1):266.e1-3. doi: 10.1016/j.ajem.2012.04.017. Epub 2012 Jun 27.
Hypothermia increases clotting time, which is known as hypothermic coagulopathy. However, prothrombin time and activated partial thromboplastin time prolongation associated with therapeutic hypothermia is usually mild and thus, hypothermic coagulopathy is not considered to cause clinically significant bleeding. On the other hand, PT and aPTT do not seem to reflect the severity of hypothermic coagulopathy. Serious bleeding complications of therapeutic hypothermia has not been reported previously. Herein, we introduce a case of spontaneous brain stem hemorrhage as a complication of therapeutic hypothermia-induced coagulopathy.
体温过低会增加凝血时间，这被称为低温性凝血障碍。然而，与治疗性低温相关的凝血酶原时间和活化部分凝血活酶时间延长通常是轻微的，因此，低温性凝血障碍不被认为会导致临床上明显的出血。另一方面，PT 和 aPTT 似乎并不能反映低温性凝血障碍的严重程度。以前没有报道过治疗性低温引起的严重出血并发症。在此，我们介绍一例因治疗性低温引起的凝血障碍导致自发性脑干出血的病例。
