Faculty of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta, Canada, T2N 4N1.
Autoimmun Rev. 2013 Jan;12(3):340-54. doi: 10.1016/j.autrev.2012.05.011. Epub 2012 Jun 25.
Autoantibodies directed against a variety of nuclear, cytoplasmic and extracellular autoantigens are a serological hallmark of systemic sclerosis. This review provides an overview of the history and clinical association of many of the autoantibodies identified in SSc sera to date. Some of these autoantibodies predate the clinical diagnosis of SSc, some are pathogenic while others have no apparent role in pathogenesis. It was once thought that the autoantibody spectrum of individual SSc sera were less complex than other systemic autoimmune rheumatic diseases with respect to heterogeneous B cell responses reflected in circulating autoantibodies. However, with the advent of array technologies, there is now an unprecedented capability to detect multiple autoantibodies in an individual serum and this long held tenet of clinical diagnostic immunology is being reexamined.
自身抗体针对各种核、细胞质和细胞外自身抗原是系统性硬化症的血清学标志。这篇综述概述了迄今为止在 SSc 血清中鉴定出的许多自身抗体的历史和临床关联。这些自身抗体中的一些先于 SSc 的临床诊断，有些是致病性的，而有些在发病机制中则没有明显作用。曾经认为，就反映循环自身抗体的异质性 B 细胞反应而言，个体 SSc 血清的自身抗体谱比其他系统性自身免疫性风湿病要简单。然而，随着阵列技术的出现，现在已经有可能在单个血清中检测到多种自身抗体，这一长期以来的临床诊断免疫学原则正在重新审视。
