Askmyr Maria, Sims Natalie A, Martin T John, Purton Louise E
St Vincent's Institute, Fitzroy, Victoria, 3065, Australia.
Trends Endocrinol Metab. 2009 Aug;20(6):303-9. doi: 10.1016/j.tem.2009.03.004.
The recently revitalized interest in the regulation of hematopoietic stem cells (HSCs) by the bone marrow microenvironment has resulted in the identification of some important cell types that potentially form the HSC niche. The term 'osteoblast' has commonly been used to describe the endosteal elements of the HSC niche, but these cells are part of a larger family that functions in bone at different stages of differentiation. Given that there is much controversy as to what cell types have important roles in the HSC niche, this review offers an overview of the diverse osteoblastic cell types and discusses the current evidence regarding what roles they have in the HSC niche.
最近，人们对骨髓微环境对造血干细胞（HSCs）的调节作用重新产生了兴趣，这使得一些可能构成造血干细胞龛位的重要细胞类型得以被识别。“成骨细胞”一词通常用于描述造血干细胞龛位的骨内膜成分，但这些细胞是在骨分化不同阶段发挥作用的更大细胞家族的一部分。鉴于关于哪些细胞类型在造血干细胞龛位中具有重要作用存在诸多争议，本综述概述了多种成骨细胞类型，并讨论了关于它们在造血干细胞龛位中所起作用的现有证据。
