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胃肠癌个体化医学概述。

Overview of personalized medicine in GI cancers.

机构信息

Division of Surgical Oncology, Department of Surgery, Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, TX, USA.

出版信息

J Gastrointest Surg. 2012 Sep;16(9):1641-4. doi: 10.1007/s11605-012-1949-8. Epub 2012 Jun 29.

DOI:10.1007/s11605-012-1949-8
PMID:22744640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3761351/
Abstract

Cancer biomarkers may be used for prevention (identification of patients at high risk for cancer), estimating prognosis and/or repsonse to conventional chemotherapies, or guide the use of specific targeted therapies. This overview provides examples in each category for gastrointestinal cancers and reviews current concepts in personalized medicine.

摘要

癌症生物标志物可用于预防(识别癌症高危患者)、评估预后和/或对常规化疗的反应,或指导特定靶向治疗的使用。本篇综述为胃肠道癌症各分类提供了相关实例,并回顾了个性化医学的现有概念。

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Overview of personalized medicine in GI cancers.胃肠癌个体化医学概述。
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2
Biomarkers for personalized medicine in GI cancers.用于胃肠道癌症个体化医学的生物标志物。
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Tumour Biol. 2014 Sep;35(9):8471-82. doi: 10.1007/s13277-014-2367-1. Epub 2014 Jul 26.

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Everolimus for advanced pancreatic neuroendocrine tumors.依维莫司治疗晚期胰腺神经内分泌肿瘤。
N Engl J Med. 2011 Feb 10;364(6):514-23. doi: 10.1056/NEJMoa1009290.
2
Sunitinib malate for the treatment of pancreatic neuroendocrine tumors.苹果酸舒尼替尼治疗胰腺神经内分泌肿瘤。
N Engl J Med. 2011 Feb 10;364(6):501-13. doi: 10.1056/NEJMoa1003825.
3
The effects of oncotype DX recurrence scores on chemotherapy utilization in a multi-institutional breast cancer cohort.Oncotype DX 复发评分对多机构乳腺癌队列中化疗应用的影响。
Breast Cancer Res Treat. 2011 Apr;126(3):797-802. doi: 10.1007/s10549-010-1329-6. Epub 2011 Jan 1.
4
Gene expression signature to improve prognosis prediction of stage II and III colorectal cancer.用于改善 II 期和 III 期结直肠癌预后预测的基因表达谱。
J Clin Oncol. 2011 Jan 1;29(1):17-24. doi: 10.1200/JCO.2010.30.1077. Epub 2010 Nov 22.
5
Prophylactic total gastrectomy for individuals with germline CDH1 mutation.预防性全胃切除术用于携带胚系 CDH1 突变的个体。
Surgery. 2011 Mar;149(3):347-55. doi: 10.1016/j.surg.2010.07.005. Epub 2010 Aug 17.
6
Relationship between tumor gene expression and recurrence in four independent studies of patients with stage II/III colon cancer treated with surgery alone or surgery plus adjuvant fluorouracil plus leucovorin.四项独立研究中,Ⅱ/Ⅲ期结肠癌患者接受单纯手术或手术加辅助氟尿嘧啶加亚叶酸治疗后,肿瘤基因表达与复发的关系。
J Clin Oncol. 2010 Sep 1;28(25):3937-44. doi: 10.1200/JCO.2010.28.9538. Epub 2010 Aug 2.
7
Prediction of adjuvant chemotherapy benefit in endocrine responsive, early breast cancer using multigene assays.多基因检测预测激素受体阳性早期乳腺癌的辅助化疗获益。
Breast. 2009 Oct;18 Suppl 3:S141-5. doi: 10.1016/S0960-9776(09)70290-5.
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Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial.局部原发性胃肠间质瘤切除术后辅助使用甲磺酸伊马替尼:一项随机、双盲、安慰剂对照试验。
Lancet. 2009 Mar 28;373(9669):1097-104. doi: 10.1016/S0140-6736(09)60500-6. Epub 2009 Mar 18.
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Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer.野生型BRAF是转移性结直肠癌对帕尼单抗或西妥昔单抗产生反应所必需的。
J Clin Oncol. 2008 Dec 10;26(35):5705-12. doi: 10.1200/JCO.2008.18.0786. Epub 2008 Nov 10.
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K-ras mutations and benefit from cetuximab in advanced colorectal cancer.K-ras突变与晚期结直肠癌患者从西妥昔单抗治疗中获益的关系
N Engl J Med. 2008 Oct 23;359(17):1757-65. doi: 10.1056/NEJMoa0804385.