Neurosciences Area, CIMA, University of Navarra, Pamplona, Spain.
Mov Disord. 2012 Aug;27(9):1178-81. doi: 10.1002/mds.25090. Epub 2012 Jun 28.
Diphasic dyskinesias are a subtype of levodopa-induced dyskinesias that appear typically at the onset and end of levodopa antiparkinsonian action. The pathophysiology of diphasic dyskinesias is not well understood.
We analyzed local field potentials recorded from the subthalamic nucleus in 7 Parkinson's disease (PD) patients who showed typical diphasic dyskinesias during postoperative recordings through a deep brain stimulation electrode. The evolution of the different oscillatory activities related to the onset and end of diphasic dyskinesias was studied by windowed fast Fourier transforms.
Typical "off"-state beta activity disappeared with the onset of diphasic dyskinesias, whereas gamma activity was absent or minimal until their end. Theta activity during diphasic dyskinesias was similar to that observed during peak-dose dyskinesias.
From a neurophysiological viewpoint, patients exhibited oscillatory activity typical of the "on" medication state during diphasic dyskinesias. The minimal presence of gamma activity during diphasic dyskinesias, however, suggests that this "on" state might be incomplete or limited to dopaminergic mechanisms affecting the lower limbs.
双相运动障碍是一种与左旋多巴相关的运动障碍，通常在左旋多巴抗帕金森病作用的开始和结束时出现。双相运动障碍的病理生理学尚不清楚。
我们分析了 7 名帕金森病（PD）患者的深部脑刺激电极记录的局部场电位，这些患者在术后记录中出现典型的双相运动障碍。通过窗口快速傅里叶变换研究了与双相运动障碍开始和结束相关的不同振荡活动的演变。
典型的“关”状态β活动随着双相运动障碍的开始而消失，而γ活动在其结束之前不存在或很少。双相运动障碍期间的θ活动与峰值剂量运动障碍期间观察到的活动相似。
从神经生理学的角度来看，患者在双相运动障碍期间表现出与“开”药状态相关的振荡活动。然而，双相运动障碍期间γ活动的存在极小，表明这种“开”状态可能不完整或仅限于影响下肢的多巴胺能机制。
