Zebrowska-Lupina I, Stelmasiak M, Porowska A
Department of Pharmacology, Medical School, Lublin, Poland.
Pol J Pharmacol Pharm. 1990 Mar-Apr;42(2):97-104.
Behavioral and biochemical effects of repeated immobilization stress were determined in male Wistar rats. The influence of acute or repeated administration of antidepressant drugs on these effects of stress were also evaluated. It was found that repeated stress (immobilization 3 h/2 degrees C/4 days or various stressors/8 days) reduced basal locomotor activity of rats and prolonged immobility time in Porsolt's despair test. Antidepressant drugs (desmethylimipramine, imipramine, amitriptyline, clomipramine, mianserine), given acutely, restored basal locomotor activity of stressed rats to control level. Desmethylimipramine, imipramine and amitriptyline reduced immobility time in Porsolt's test similarly in control as in stressed rats. However clomipramine, mianserine and trazodone were effective in this test only in stressed rats. Imipramine given for 4 or 8 days (1 h before the stressor) normalized basal locomotor activity. Repeated (for 8 days) various stressors decelerated utilization of noradrenaline (NA) and dopamine (DA) in the brain. Imipramine given once a day for 8 days (1 h before the stressor) normalized brain utilization of catecholamines (CA). It was proposed that depression of basal motility and reduction of CA utilization in the brain induced by repeated stress may be counter acted by antidepressant drugs.
在雄性Wistar大鼠中确定了重复固定应激的行为和生化效应。还评估了抗抑郁药物急性或重复给药对这些应激效应的影响。结果发现，重复应激（3小时固定于2℃/4天或多种应激源/8天）降低了大鼠的基础运动活性，并延长了波索尔特绝望试验中的不动时间。急性给予抗抑郁药物（去甲丙咪嗪、丙咪嗪、阿米替林、氯米帕明、米安色林）可将应激大鼠的基础运动活性恢复至对照水平。去甲丙咪嗪、丙咪嗪和阿米替林在对照大鼠和应激大鼠中同样能减少波索尔特试验中的不动时间。然而，氯米帕明、米安色林和曲唑酮仅在应激大鼠中对该试验有效。丙咪嗪给药4天或8天（在应激源前1小时）可使基础运动活性恢复正常。重复（8天）给予多种应激源会减缓大脑中去甲肾上腺素（NA）和多巴胺（DA）的利用。丙咪嗪每天给药1次，共8天（在应激源前1小时）可使大脑中儿茶酚胺（CA）的利用恢复正常。有人提出，重复应激诱导的基础运动性降低和大脑中CA利用减少可能会被抗抑郁药物抵消。
