Zebrowska-Lupina I, Ossowska G, Klenk-Majewska B
Department of Pharmacology, Medical Academy, Lublin, Poland.
Pol J Pharmacol Pharm. 1992 Jul-Aug;44(4):325-35.
The influence of dopamine (DA) receptor blockers (haloperidol, sulpiride) on electric footshock-induced fighting behavior and on the effect of antidepressants (imipramine, clomipramine, nomifensine, mianserine) was investigated in chronically stressed male Wistar rats. Exploratory activity in an open field was measured in the same groups of animals. The effect of chronic stress and antidepressants on DA utilization in the brain was also investigated. It was shown that 48 h after the last session of repeated stress (various unpredictable stressors over 16 days) the number of fighting attacks was significantly reduced. However in stressed rats treated chronically (for 14 days) with antidepressants the intensity of fighting was restored to control value. On the contrary, when the stressed rats, receiving antidepressants chronically, were pretreated with DA receptor blockers: haloperidol (0.5 mg/kg) or sulpiride (50 mg/kg) but also alpha 1-adrenergic receptor blocker - prazosin (3 mg/kg) the effect of antidepressants was abolished. Exploratory activity was not significantly reduced under influence of stress. Neither antidepressants nor sulpiride modified exploratory activity of stressed rats. Haloperidol and prazosin but not sulpiride decreased this activity of normal, stressed and antidepressant-treated rats. It is concluded that prolonged treatment with antidepressants counteracts the decrease in aggression induced by chronic stress and that DA mechanism participate in this effect of antidepressant drugs.
在长期应激的雄性Wistar大鼠中，研究了多巴胺（DA）受体阻滞剂（氟哌啶醇、舒必利）对电休克诱导的格斗行为以及对抗抑郁药（丙咪嗪、氯米帕明、诺米芬辛、米安色林）效果的影响。在同一组动物中测量了旷场中的探究活动。还研究了慢性应激和抗抑郁药对大脑中DA利用的影响。结果显示，在最后一次重复应激（16天内各种不可预测的应激源）结束48小时后，格斗攻击次数显著减少。然而，在长期（14天）接受抗抑郁药治疗的应激大鼠中，格斗强度恢复到对照值。相反，当长期接受抗抑郁药治疗的应激大鼠预先用DA受体阻滞剂：氟哌啶醇（0.5mg/kg）或舒必利（50mg/kg），以及α1肾上腺素能受体阻滞剂哌唑嗪（3mg/kg）预处理时，抗抑郁药的效果被消除。在应激影响下，探究活动没有显著降低。抗抑郁药和舒必利均未改变应激大鼠的探究活动。氟哌啶醇和哌唑嗪而非舒必利降低了正常、应激和接受抗抑郁药治疗大鼠的这种活动。结论是，长期使用抗抑郁药可抵消慢性应激诱导的攻击行为减少，并且DA机制参与了抗抑郁药的这种作用。
