Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
Int J Clin Pharm. 2012 Oct;34(5):728-32. doi: 10.1007/s11096-012-9667-6. Epub 2012 Jun 29.
Beyond the direct pharmacological effect of medicines, preferences and perceptions toward a particular oral solid dosage form (OSDF) play a crucial role in recovery and may reduce adherence to the prescribed treatment.
This study conducted to investigate the most preferred OSDF and the degree to which swallowing solid medication is an issue, to assess perceptions of the therapeutic benefits of the OSDF, and to find predictors of the most preferred OSDF.
A cross-sectional study, through convenience sample method, was conducted to survey consumers visiting community pharmacies in Baghdad, Iraq. Data was collected by self-administered and pre-piloted questionnaires, and analyzed using Statistical Package for Social Science. Multiple logistic regression analysis and Chi-square tests were used at alpha level = 0.05.
A total of 1,000 questionnaire were included in the analysis. Of all respondents, 52.9 % preferred capsule among other OSDF and this preference varied significantly with a number of socio-demographic factors. Ease of swallowing solid medication was the main issue which resulted in preferences for a particular form. A negative perception of the therapeutic benefits of the OSDF was found among 89.1 % of the consumers. Multiple logistic regression analysis indicated that gender, ease of swallowing, and perceptions of the therapeutic benefits of the OSDF were significant predictors of capsule preferences.
Given the fact that consumers are the end users of medicines and their preferences may influence response to the treatment, efforts are worthwhile by the prescribers and medicines' manufactures to understand consumers' preferences of a particular dosage form in order to achieve successful therapy outcomes.
除了药物的直接药理作用外,患者对特定口服固体制剂(OSDF)的偏好和认知在康复中起着至关重要的作用,并可能降低对规定治疗的依从性。
本研究旨在调查患者最偏好的 OSDF 以及吞咽固体药物的困难程度,评估对 OSDF 治疗益处的认知,并寻找最偏好的 OSDF 的预测因素。
采用横断面研究方法,通过便利抽样法对伊拉克巴格达社区药店的消费者进行调查。通过自填式和预试点问卷收集数据,并使用社会科学统计软件包进行分析。采用多元逻辑回归分析和卡方检验,显著性水平设为 0.05。
共纳入 1000 份问卷进行分析。在所有受访者中,52.9%更喜欢胶囊,这种偏好因多种社会人口学因素而显著不同。吞咽固体药物的便利性是导致偏好特定剂型的主要问题。89.1%的消费者对 OSDF 的治疗益处存在负面认知。多元逻辑回归分析表明,性别、吞咽的便利性以及对 OSDF 治疗益处的认知是胶囊偏好的显著预测因素。
鉴于消费者是药物的最终使用者,他们的偏好可能会影响对治疗的反应,因此,处方者和药物制造商值得努力了解消费者对特定剂型的偏好,以实现成功的治疗效果。