Kurczewska-Michalak Marta, Kardas Przemysław, Czajkowski Mikolaj
Department of Family Medicine, Medical University of Lodz, 60, Narutowicza St, 90-136 Lodz, Poland.
Department of Economics, University of Warsaw, 00-241 Warsaw, Poland.
Pharmaceutics. 2020 Mar 6;12(3):236. doi: 10.3390/pharmaceutics12030236.
Personal preferences play an important role in the patients' decision process whether to adhere to treatment, or not. The purpose of this study is to assess Polish outpatients' preferences for solid forms of oral medications across various scenarios.
The convenience sample of 200 outpatients took part in this study. According to the discrete choice experiment (DCE) design, participants were provided with selection of tablets and capsules, in different shapes, sizes, colors, and copayment levels and were asked to state their preferences. DCE results were analyzed using mixed logit (MXL) models.
MXL models revealed patients' willingness to pay for various solid forms of medications. The most preferred combination of drug parameters were: small yellow capsule for chronic treatment, and small yellow long tablet for short-term treatment. Study participants were happy to pay extra 6.52 PLN (≈1.63 EUR) for this drug formulation per month of antihypertensive treatment, and 14.44 PLN (≈3.61 EUR) for this drug formulation per 7-days' long course of antibiotic treatment, respectively.
Results suggest that color, shape, and size of solid form of oral medications are important predictors of patients' acceptance. It can not only be expressed in monetary value, but also may serve as an important hint for companies designing new drugs, or policymakers who are happy to improve patient adherence with better prescribing, or dispensing. However, our findings are probably country-specific, and further research is necessary to better understand the relationship between solid drug characteristics, and patient's preferences across countries.
个人偏好在患者决定是否坚持治疗的过程中起着重要作用。本研究的目的是评估波兰门诊患者在各种情况下对固体剂型口服药物的偏好。
200名门诊患者的便利样本参与了本研究。根据离散选择实验(DCE)设计,为参与者提供了不同形状、大小、颜色和自付费用水平的片剂和胶囊供其选择,并要求他们表明自己的偏好。使用混合逻辑(MXL)模型分析DCE结果。
MXL模型揭示了患者为各种固体剂型药物支付的意愿。最受青睐的药物参数组合是:用于慢性治疗的小黄胶囊,以及用于短期治疗的小黄长片。研究参与者分别愿意为这种抗高血压治疗药物配方每月额外支付6.52兹罗提(约合1.63欧元),为这种抗生素治疗7天疗程的药物配方每疗程额外支付14.44兹罗提(约合3.61欧元)。
结果表明,口服药物固体剂型的颜色、形状和大小是患者接受程度的重要预测因素。它不仅可以用货币价值来表示,还可能为设计新药的公司或乐于通过更好的处方或配药来提高患者依从性的政策制定者提供重要提示。然而,我们的研究结果可能具有国别特异性,需要进一步研究以更好地理解固体药物特性与各国患者偏好之间的关系。