Siregar Parlindungan
Department of Internal Medicine, Faculty of Medicine, University of Indonesia - Cipto Mangunkusumo Hospital. Jl. Diponegoro no. 71, Jakarta Pusat 10430, Indonesia.
Acta Med Indones. 2012 Apr;44(2):150-3.
Primary hyperaldosteronism or Conn syndrome is the syndrome formed from the triad of hypertension, hypokalemia, and metabolic alkalosis. Six patients of Conn syndrome, two females (21 and 50 years) and 4 males (30, 33, 46, dan 51 years), were reported. All of the cases came with the symptoms of weakness of the lower extremities in conjunction with hypertension. The plasma aldosterone level was high with the very low plasma renin activity in all of the cases. All of the patients in this case had metabolic alkalosis. Unilateral adrenal mass was found on CT-Scan or MRI imaging. Following adrenalectomy, three patients (one female and two males) still needed one type of anti hypertension drug. All of the patients did not require anti aldosterone anymore. The plasma aldosterone returned to normal value in three patients while in three other patients were not checked. The histopathology of the adrenal revealed the adenoma of the adrenal cortex in all of the six cases.
原发性醛固酮增多症或Conn综合征是由高血压、低钾血症和代谢性碱中毒三联征组成的综合征。报告了6例Conn综合征患者，2例女性（21岁和50岁）和4例男性（30岁、33岁、46岁和51岁）。所有病例均伴有下肢无力症状及高血压。所有病例血浆醛固酮水平升高而血浆肾素活性极低。该病例所有患者均有代谢性碱中毒。CT扫描或MRI成像发现单侧肾上腺肿块。肾上腺切除术后，3例患者（1例女性和2例男性）仍需一种抗高血压药物。所有患者不再需要抗醛固酮药物。3例患者血浆醛固酮恢复正常，另外3例未检查。肾上腺组织病理学检查显示6例均为肾上腺皮质腺瘤。
