Martínez José Joaquín Alfaro, Oliveira Cristina Lamas, Meneses Amparo Lomas, Rodríguez Silvia Aznar, Corrales Pedro Pinés, López Antonio Hernández, Romero Francisco Botella
Sección de Endocrinología y Nutrición, Complejo Hospitalario Universitario de Albacete, Facultad de Medicina, Universidad de Castilla-La Mancha, Albacete, España.
Endocrinol Nutr. 2009 Oct;56(8):431-4. doi: 10.1016/S1575-0922(09)72715-9.
Rhabdomyolysis may be secondary to trauma, excessive muscle activity, hereditary muscle enzyme defects and other medical causes. Primary hyperaldosteronism is characterised by hypertension, hypokalemia, suppressed plasma renin activity, and increased aldosterone excretion. Rhabdomyolysis is not common in primary hyperaldosteronism. We report here a 42-year-old woman presenting with rhabdomyolysis as heralding symptom of primary hyperaldosteronism. We also carried out a search of the literature to identify all cases of rhabdomyolysis as the first-recognized expression of a primary hyperaldosteronism. Sixteen cases met the criteria for inclusion. When rhabdomyolysis occurs in a patient with hypokalemia and metabolic alkalosis, primary hyperaldosteronism has to be suspected: if confirmed, an aldosterone-producing adenoma is the most probable cause.
横纹肌溶解症可能继发于创伤、过度的肌肉活动、遗传性肌肉酶缺陷及其他医学原因。原发性醛固酮增多症的特征为高血压、低钾血症、血浆肾素活性受抑制以及醛固酮排泄增加。横纹肌溶解症在原发性醛固酮增多症中并不常见。我们在此报告一名42岁女性，其以横纹肌溶解症作为原发性醛固酮增多症的先兆症状。我们还检索了文献以确定所有将横纹肌溶解症作为原发性醛固酮增多症首次识别表现的病例。16例符合纳入标准。当横纹肌溶解症发生在低钾血症和代谢性碱中毒患者中时，必须怀疑原发性醛固酮增多症：如果得到证实，醛固酮瘤是最可能的病因。
