Muliawati Yanti, Haroen Harlinda, Rotty Linda W A
Department of Internal Medicine, Faculty of Medicine, University of Sam Ratulangi-Prof. dr. R.D. Kandou Hospital. Jl. Raya Tanawangko, Manado 95115, Indonesia.
Acta Med Indones. 2012 Apr;44(2):154-62.
Cancer anorexia-cachexia syndrome (CACS) is a devastating and debilitating aspect at any stage of malignancy. It presents primarily as anorexia, weight loss and muscle wasting secondary to inadequate oral intake and metabolic changes. This syndrome is highly prevalent among cancer patients, has a large impact on morbidity and mortality, and impinges on patient quality of life. The pathogenic mechanisms of CACS are multifactorial. It is suggested to be the result of tumor-host interactions and cytokines have a siginificant role. Diagnosis of cancer cachexia is complex and multifaceted and requires meticulous clinical examination of the patient. The challenge for clinicians is to know how best to manage the symptoms of weight loss and anorexia for optimal patient outcome. This article outlines the diagnosis of cancer cachexia, reviews its impact on patient quality of life and survival, and updates the reader on potential therapies that may suppress it.
癌症恶病质综合征（CACS）是恶性肿瘤任何阶段都存在的一种严重且使人衰弱的情况。它主要表现为厌食、体重减轻以及因口服摄入量不足和代谢变化继发的肌肉消耗。这种综合征在癌症患者中非常普遍，对发病率和死亡率有很大影响，并影响患者的生活质量。CACS的发病机制是多因素的。它被认为是肿瘤与宿主相互作用的结果，细胞因子起重要作用。癌症恶病质的诊断复杂且多方面，需要对患者进行细致的临床检查。临床医生面临的挑战是要知道如何最好地处理体重减轻和厌食症状以实现最佳的患者预后。本文概述了癌症恶病质的诊断，回顾了其对患者生活质量和生存的影响，并向读者介绍了可能抑制它的潜在治疗方法。
