Guidetti Gianni Francesco, Torti Mauro
Department of Biology and Biotechnology, Division of Biochemistry, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.
J Signal Transduct. 2012;2012:412089. doi: 10.1155/2012/412089. Epub 2012 Jun 14.
Integrins and other families of cell adhesion receptors are responsible for platelet adhesion and aggregation, which are essential steps for physiological haemostasis, as well as for the development of thrombosis. The modulation of platelet adhesive properties is the result of a complex pattern of inside-out and outside-in signaling pathways, in which the members of the Rap family of small GTPases are bidirectionally involved. This paper focuses on the regulation of the main Rap GTPase expressed in circulating platelets, Rap1b, downstream of adhesion receptors, and summarizes the most recent achievements in the investigation of the function of this protein as regulator of platelet adhesion and thrombus formation.
整合素和其他细胞黏附受体家族负责血小板的黏附和聚集，这是生理性止血以及血栓形成的关键步骤。血小板黏附特性的调节是由复杂的外向内和内向外交联信号通路模式导致的，其中小GTP酶Rap家族成员双向参与其中。本文聚焦于循环血小板中表达的主要Rap GTP酶Rap1b在黏附受体下游的调节作用，并总结了该蛋白作为血小板黏附和血栓形成调节因子功能研究的最新成果。
