从经典到非常规：促进血小板对感染和炎症反应的免疫受体
From Classical to Unconventional: The Immune Receptors Facilitating Platelet Responses to Infection and Inflammation.
作者信息
Gautam Iluja, Storad Zachary, Filipiak Louis, Huss Chadwick, Meikle Claire K, Worth Randall G, Wuescher Leah M
机构信息
Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
出版信息
Biology (Basel). 2020 Oct 20;9(10):343. doi: 10.3390/biology9100343.
Platelets have long been recognized for their role in maintaining the balance between hemostasis and thrombosis. While their contributions to blood clotting have been well established, it has been increasingly evident that their roles extend to both innate and adaptive immune functions during infection and inflammation. In this comprehensive review, we describe the various ways in which platelets interact with different microbes and elicit immune responses either directly, or through modulation of leukocyte behaviors.
长期以来，血小板在维持止血和血栓形成之间的平衡中所起的作用已得到公认。虽然它们在血液凝固中的作用已得到充分证实，但越来越明显的是，在感染和炎症过程中，它们的作用扩展到先天性和适应性免疫功能。在这篇全面的综述中，我们描述了血小板与不同微生物相互作用的各种方式，以及它们直接或通过调节白细胞行为引发免疫反应的方式。
Zotero 插件