Dental Biomaterials Adverse Reaction Unit, Uni Health, Uni Research, Bergen, Norway.
Acta Odontol Scand. 2013 May-Jul;71(3-4):560-9. doi: 10.3109/00016357.2012.697577. Epub 2012 Jul 2.
Some patients attribute health complaints to amalgam fillings and report improvement of health after replacement of amalgam fillings. The aim of the present study was to characterize the changes of different health complaints after replacement of amalgam fillings and compare with an external reference group from the general population.
The study group included 20 patients with health complaints attributed to amalgam fillings who were participants in the treatment group of a clinical trial at the Norwegian Dental Biomaterials Adverse Reaction Unit. The patients were asked to indicate the intensity of local and general health complaints on numeric rating scales (0-10) before removal of amalgam fillings and at follow-up 3 years after removal. Data from the patient group were compared with data from an external reference group (n = 441).
Before treatment the mean intensity of complaints were on a higher level in the treatment group compared to the reference group. The most frequently reported complaints in the treatment group were gastrointestinal symptoms, fatigue, pain from muscles and joints, symptoms from ear/nose/throat and difficulty concentrating. From pre-treatment examination to the 3-year follow-up 20 of 23 health complaints decreased, being statistically significant for taste disturbances, pain from muscles and joints, gastrointestinal complaints, complaints from ear/nose/throat and fatigue.
The inter-individual variation of intensities of health complaints was considerable and the reduction of health complaints varied for the different complaints. Several factors may be of importance for the observed reduction of complaint intensity.
一些患者将健康问题归因于汞合金填充物，并报告在更换汞合金填充物后健康状况有所改善。本研究的目的是描述更换汞合金填充物后不同健康问题的变化，并与一般人群中的外部参考组进行比较。
研究组包括 20 名因汞合金填充物而出现健康问题的患者，他们是挪威牙科生物材料不良反应单位临床试验治疗组的参与者。患者被要求在去除汞合金填充物之前和去除后 3 年的随访中使用数字评分量表（0-10）来表示局部和整体健康问题的严重程度。患者组的数据与外部参考组（n=441）的数据进行比较。
在治疗前，治疗组的投诉强度平均值高于参考组。治疗组最常报告的投诉是胃肠道症状、疲劳、肌肉和关节疼痛、耳/鼻/喉症状和注意力不集中。从治疗前检查到 3 年随访，23 项健康投诉中有 20 项减少，味觉障碍、肌肉和关节疼痛、胃肠道投诉、耳/鼻/喉投诉和疲劳的减少具有统计学意义。
健康投诉强度的个体间差异很大，不同投诉的投诉减少程度也不同。观察到的投诉强度的降低可能与几个因素有关。
