Lygre G B, Grønningsaeter A G, Gjerdet N R
Det odontologiske fakultet Universitetet i Bergen.
Tidsskr Nor Laegeforen. 1998 Apr 30;118(11):1698-701.
During 1993-95 a total of 169 patients (112 women, 57 men) with a wide range of complaints associated with earlier or present amalgam fillings were seen by the "Dental Biomaterials Adverse Reaction Unit" in Norway. Most patients had amalgam fillings; 19 had removed all amalgam, and 14 were in the process of replacing the amalgam fillings with other materials. Predominant symptoms were of a subjective and general nature (96% of the patients). Muscle and joint pain, headache, dizziness and feeling exhausted comprised the most common symptoms. Intra-oral pathology was observed in 48%. There was a correlation between the amount of amalgam ("amalgam score") and urinary mercury. Those without amalgam fillings and significantly lower values (median = 1.6 micrograms mercury/g creatinine) than those with amalgam fillings (medians: with amalgam = 3.5 micrograms/g; with partial removal of amalgam = 2.7 micrograms/g). Overall, in the present group of patients, no statistically significant correlation seemed to exist between the type and number of subjective symptoms or objective findings and the urinary mercury. This would indicate therefore that there is no straightforward association between urinary mercury and symptoms in the present group of patients.
1993年至1995年期间，挪威的“牙科生物材料不良反应小组”接待了169名患者（112名女性，57名男性），他们有各种各样与早期或现有的汞合金填充物相关的不适症状。大多数患者有汞合金填充物；19名患者已去除所有汞合金，14名患者正在用其他材料替换汞合金填充物。主要症状具有主观和全身性（96%的患者）。肌肉和关节疼痛、头痛、头晕和疲惫感是最常见的症状。48%的患者观察到口腔内病变。汞合金含量（“汞合金评分”）与尿汞之间存在相关性。没有汞合金填充物的患者尿汞值（中位数 = 1.6微克汞/克肌酐）明显低于有汞合金填充物的患者（中位数：有汞合金 = 3.5微克/克；部分去除汞合金 = 2.7微克/克）。总体而言，在本组患者中，主观症状或客观检查结果的类型和数量与尿汞之间似乎不存在统计学上的显著相关性。因此，这表明在本组患者中尿汞与症状之间没有直接关联。
