Coccaro E F, Gabriel S, Siever L J
Department of Psychiatry, Medical College of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia 19129.
Psychopharmacol Bull. 1990;26(3):393-405.
The prolactin (PRL) response to challenge with buspirone hydrochloride, a serotonin1a (5-HT1a) receptor agonist, was examined in 5 healthy male volunteers and in 10 healthy male and female patients with primary DSM-III personality disorder. In healthy volunteers, pretreatment with the nonselective 5-HT receptor antagonist, metergoline (4 mg p.o.) completely suppressed the maximal PRL response to buspirone challenge. Pretreatment with the nonselective beta-adrenergic/5-HT1-like antagonist, pindolol suppressed the maximal PRL response to buspirone challenge depending upon dose (i.e., between 49 to 90% suppression at best dose). In personality disorder patients, PRL responses to buspirone challenge correlated inversely with self-assessed "irritability" (r = -.76, n = 10, p less than .01). These data suggest that the PRL response to buspirone challenge reflects the responsivity of 5-HT1a receptors in the limbic-hypothalamus in humans and that reduced sensitivity of these receptors is associated with an important component of impulsive aggressive behaviors in personality disorder patients.
在5名健康男性志愿者以及10名患有原发性DSM-III人格障碍的健康男性和女性患者中，研究了催乳素（PRL）对5-羟色胺1a（5-HT1a）受体激动剂盐酸丁螺环酮激发试验的反应。在健康志愿者中，用非选择性5-HT受体拮抗剂美替拉酮（口服4毫克）进行预处理可完全抑制对丁螺环酮激发试验的最大PRL反应。用非选择性β-肾上腺素能/5-HT1样拮抗剂吲哚洛尔进行预处理，根据剂量抑制对丁螺环酮激发试验的最大PRL反应（即，在最佳剂量下抑制49%至90%）。在人格障碍患者中，对丁螺环酮激发试验的PRL反应与自我评估的“易怒性”呈负相关（r = -0.76，n = 10，p < 0.01）。这些数据表明，对丁螺环酮激发试验的PRL反应反映了人类边缘下丘脑5-HT1a受体的反应性，并且这些受体的敏感性降低与人格障碍患者冲动攻击行为的一个重要组成部分有关。
