Hennig J, Kroeger A, Meyer B, Prochaska H, Krien P, Huwe S, Netter P
Department of Psychology, University of Giessen, FRG.
Pharmacopsychiatry. 1998 Jan;31(1):19-24. doi: 10.1055/s-2007-979290.
The present study was conducted to investigate if personality traits can be usefully related to serotonergic vs. dopaminergic action of the 5-HT1a-antagonist +/- pindolol. Forty healthy male volunteers (aged between 20 and 30 years) were randomly assigned to a placebo or a +/- pindolol (30 mg, oral dose) group in a double blind trial. Blood samples were drawn and analyzed for PRL concentrations. In addition, the subjects completed questionnaires on personality. The results indicated that +/- pindolol decreases PRL concentrations depending on personality. While subjects high on impulsivity and related traits (aggression and disinhibition) show lower PRL decreases, well-being and personality traits frequently related to dopaminergic activity were not correlated with changes in PRL. Since reduced (blunted) PRL-responses after 5-HT challenge tests have been reported for impulsives, the present results favor the involvement of primarily serotonergic and probably only secondarily dopaminergic control of +/- pindolol induced PRL decreases.
本研究旨在调查人格特质是否能有效地与5-羟色胺1a拮抗剂±吲哚洛尔的血清素能与多巴胺能作用相关联。在一项双盲试验中，40名健康男性志愿者（年龄在20至30岁之间）被随机分配到安慰剂组或±吲哚洛尔（30毫克，口服剂量）组。采集血样并分析催乳素浓度。此外，受试者完成了关于人格的问卷调查。结果表明，±吲哚洛尔降低催乳素浓度取决于人格。虽然冲动性及相关特质（攻击性和去抑制）得分高的受试者催乳素降低幅度较小，但幸福感和经常与多巴胺能活动相关的人格特质与催乳素的变化无关。由于有报道称冲动者在5-羟色胺激发试验后催乳素反应降低（迟钝），目前的结果支持±吲哚洛尔诱导的催乳素降低主要涉及血清素能控制，可能仅次要涉及多巴胺能控制。
