Scopsi L, Pilotti S, Rilke F
Division of Anatomic Pathology and Cytology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
Regul Pept. 1990 Sep 10;30(2):89-104. doi: 10.1016/0167-0115(90)90050-7.
An increasing number of regulatory peptides not coded by the calcitonin genes are known to occur in the thyroid C cells. We have now carried out light and electron microscopic immunocytochemical analyses on specimens of normal human thyroids and medullary carcinomas to establish the occurrence of members of the PP-PYY-NPY family in the C cell system. By means of site-directed immunocytochemistry we provide the first evidence that a molecule closely related to proNPY is present in normal and pathologic C cells, and is co-stored with calcitonin in the cytoplasmic dense-core granules. Preliminary observations also suggest that high levels of expression of NPY-gene products help to define a subset of tumours with a less aggressive behaviour.
已知越来越多并非由降钙素基因编码的调节肽存在于甲状腺C细胞中。我们现已对正常人甲状腺和髓样癌标本进行了光镜和电镜免疫细胞化学分析，以确定PP-PYY-NPY家族成员在C细胞系统中的存在情况。通过定位免疫细胞化学，我们首次证明一种与前神经肽Y密切相关的分子存在于正常和病理状态的C细胞中，并与降钙素共同储存于细胞质致密核心颗粒中。初步观察还表明，神经肽Y基因产物的高表达有助于定义行为较不具侵袭性的肿瘤亚群。
