Department of Psychiatry and Psychotherapy, Georg-August-University Göttingen, Göttingen, Germany.
Int J Psychiatry Clin Pract. 2013 Jun;17(2):148-53. doi: 10.3109/13651501.2012.704384. Epub 2012 Aug 6.
The aim of this naturalistic study was to assess course and predictors of symptomatic remission in outpatients with first-episode psychosis during quetiapine monotherapy.
In 131 outpatients presenting with first-episode psychosis, socio-demographic and clinical variables including PANSS-8 and CGI-S scores were compared at baseline and follow-up between the subgroups with and without symptomatic remission during 12 weeks of flexible-dose treatment with quetiapine.
Logistic regression revealed a low degree of negative symptoms at baseline, younger age, shorter duration of psychotic episode, early treatment response, and the absence of concomitant diseases as predictors for symptomatic remission whereas general disease severity, PANSS-8 total score, gender, alcohol or substance abuse had no predictive value.
Our study underlines the predictive value of early treatment response and a low degree of negative symptoms in outpatients with first-episode psychosis. It also confirms the usability of the symptomatic remission criterion as a cross-sectional threshold criterion in clinical practice.
本自然主义研究旨在评估首发精神病患者接受喹硫平单药治疗期间症状缓解的过程和预测因素。
在 131 名首发精神病患者中，比较了基线和随访时在接受喹硫平灵活剂量治疗的 12 周内有和无症状缓解亚组之间的社会人口统计学和临床变量，包括 PANSS-8 和 CGI-S 评分。
逻辑回归显示，基线时阴性症状程度较低、年龄较小、精神病发作持续时间较短、早期治疗反应以及无合并症是症状缓解的预测因素，而一般疾病严重程度、PANSS-8 总分、性别、酒精或物质滥用则无预测价值。
本研究强调了首发精神病患者早期治疗反应和较低程度的阴性症状的预测价值。它还证实了症状缓解标准作为临床实践中横断面阈值标准的可用性。
