Morillas Pedro, Quiles Juan, Mateo Irene, Bertomeu-González Vicente, Castillo Jesus, de Andrade Helder, Roldán Julián, Miralles Beatriz, Masiá María Dolores, Carrillo Pilar, Bertomeu-Martínez Vicente
Arterial Hypertension Unit, Cardiology Department, Hospital Universitario de San Juan, Alicante, Spain.
Blood Press. 2012 Dec;21(6):360-6. doi: 10.3109/08037051.2012.694181. Epub 2012 Jul 3.
The resistive index (RI) is a hemodynamic parameter that reflects local wall extensibility and related vascular resistance. We analyze the relationship between common carotid RI and target organ damage in treated hypertensive patients.
We analyzed 265 consecutive hypertensive patients. Risk factors, cardiovascular history and treatments were collected; blood test, urinary albumin excretion (UAE), echocardiography to determine left ventricular mass index (LVMI), ankle-brachial index (ABI) and carotid echo-Doppler ultrasound to calculate the carotid intima-media thickness (IMT) and RI of both common carotids arteries were performed.
A positive correlation was found between carotid RI and age, systolic blood pressure, heart rate, carotid IMT, LVMI, UAE and a negative correlation was found with diastolic blood pressure and ABI. Subjects at the top quartile of carotid RI showed a higher prevalence of left ventricular hypertrophy and peripheral artery disease (increased IMT, carotid plaques and lower ABI) compared with those with low RI (p < 0.05). Multiple regression analysis demonstrated that age, systolic and diastolic blood pressure and LVMI independently influence carotid RI.
Carotid RI is related with age, systolic-diastolic blood pressure and LVMI in hypertensive patient. This evaluation could predict the presence of early cardiovascular damage and provide an accurate estimation of overall risk in this population.
阻力指数（RI）是一种血流动力学参数，反映局部血管壁可扩展性及相关血管阻力。我们分析经治疗的高血压患者颈总动脉RI与靶器官损害之间的关系。
我们分析了265例连续的高血压患者。收集危险因素、心血管病史及治疗情况；进行血液检查、尿白蛋白排泄率（UAE）、超声心动图以测定左心室质量指数（LVMI）、踝臂指数（ABI）以及颈动脉回声多普勒超声检查以计算双侧颈总动脉的颈动脉内膜中层厚度（IMT）和RI。
发现颈动脉RI与年龄、收缩压、心率、颈动脉IMT、LVMI、UAE呈正相关，与舒张压和ABI呈负相关。与低RI患者相比，颈动脉RI处于最高四分位数的受试者左心室肥厚和外周动脉疾病（IMT增加、颈动脉斑块及ABI降低）的患病率更高（p < 0.05）。多元回归分析表明年龄、收缩压、舒张压和LVMI独立影响颈动脉RI。
高血压患者的颈动脉RI与年龄、收缩压 - 舒张压及LVMI相关。该评估可预测早期心血管损害的存在，并准确估计该人群的总体风险。
