Furuse M, Yang S I, Muramatsu T, Okumura J
Laboratory of Animal Nutrition, School of Agriculture, Nagoya University, Japan.
Scand J Gastroenterol. 1990 Dec;25(12):1242-6. doi: 10.3109/00365529008998560.
Whether ingestion of soya-bean trypsin inhibitor (SBTI) alters the release of cholecystokinin (CCK) was investigated in chickens. A meal of an adequate diet supplemented with SBTI (0, 100, or 1000 mg/kg) was given through a stomach tube, followed by CCK determination with specific CCK-8 antibody. The plasma CCK level increased from a basal level (control diet) of 9.6 +/- 0.6 to 13.4 +/- 0.6 and 18.1 +/- 0.8 fmol/ml plasma at 90 min after feeding the diet supplemented with 100 and 1000 mg SBTI, respectively. Since the SBTI supplementation did not affect crop emptying rates significantly, it was concluded that SBTI by itself enhanced CCK release into circulation in a dose-dependent fashion.
研究了鸡摄入大豆胰蛋白酶抑制剂（SBTI）是否会改变胆囊收缩素（CCK）的释放。通过胃管给鸡喂食补充了SBTI（0、100或1000mg/kg）的充足日粮，然后用特异性CCK-8抗体测定CCK。喂食补充100mg和1000mg SBTI的日粮后90分钟，血浆CCK水平分别从基础水平（对照日粮）的9.6±0.6升高至13.4±0.6和18.1±0.8fmol/ml血浆。由于补充SBTI对嗉囊排空率没有显著影响，因此得出结论，SBTI本身以剂量依赖的方式增强了CCK向循环中的释放。
