Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, 451, Smyth Road, Ottawa, Ontario, K1H 8 M5, Canada.
BMC Pulm Med. 2012 Jun 29;12:32. doi: 10.1186/1471-2466-12-32.
Pulmonary function is not fully reversible in asthma in children and may continue into adult life. This study was to determine the association between asthma and reduced pulmonary function in adults and the modification by sex and atopic status.
A cross-sectional study of 1492 adults aged 18 years or over was conducted in a rural community. Atopy, height, weight, waist circumference (WC) and pulmonary function were measured. Participants with ever asthma were those who reported by questionnaire a history of asthma diagnosed by a physician during lifetime. Participants who had former (only) asthma were those who reported having physician-diagnosed asthma more than 12 months ago. Participants who had recent asthma were those who reported having asthma during the last 12 months.
Men had higher values of forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) compared with women, but FEV1/FVC ratio showed no significant difference between sexes. Atopic status was not related to pulmonary function and the average values of the pulmonary function testing variables were almost the same for non-atopic and atopic individuals. Individuals with ever, recent or former asthma had significant lower values of FEV1 and FEV1/FVC ratio than those who reported having no asthma, and the associations tended to be stronger in men than in women. The interaction between atopy and asthma was not statistically significant.
Adults who reported having recent asthma or former asthma had reduced pulmonary function, which was significantly modified by sex but not by atopic status.
儿童哮喘的肺功能不完全可逆，并且可能持续到成年期。本研究旨在确定哮喘与成年人肺功能下降之间的关联，以及性别和特应性状态的修饰作用。
对一个农村社区的 1492 名 18 岁或以上的成年人进行了横断面研究。测量了特应性、身高、体重、腰围（WC）和肺功能。曾患有哮喘的参与者是指通过问卷报告一生中曾由医生诊断为哮喘的病史。曾患有（仅）哮喘的参与者是指报告曾在 12 个月前被医生诊断为哮喘的人。近期患有哮喘的参与者是指报告在过去 12 个月内患有哮喘的人。
男性的用力肺活量（FVC）和第一秒用力呼气量（FEV1）值高于女性，但 FEV1/FVC 比值在性别之间无显著差异。特应性状态与肺功能无关，非特应性和特应性个体的肺功能检测变量的平均值几乎相同。曾患有、近期患有或曾患有哮喘的个体的 FEV1 和 FEV1/FVC 比值明显低于报告无哮喘的个体，且这些关联在男性中比女性更强。特应性和哮喘之间的相互作用无统计学意义。
报告近期或曾患有哮喘的成年人的肺功能下降，这种情况显著受性别影响，但不受特应性状态影响。
