Department of Pediatrics, Stavanger University Hospital, Stavanger, Norway; Department of Clinical Science, University of Bergen, Norway.
Department of Pediatrics, Stavanger University Hospital, Stavanger, Norway.
Respir Med. 2020 Aug-Sep;170:106063. doi: 10.1016/j.rmed.2020.106063. Epub 2020 Jun 15.
Both inflammatory and mechanical effects have been proposed to explain the increased risk of asthma and reduced lung function observed in obese children and adults. The evidence regarding the potential role of obesity in the aetiology of atopy and allergy is more conflicting. The adipokines leptin and adiponectin are inflammatory markers of fat metabolism which may be involved in explaining the increased risk of asthma and reduced lung function in obese children and adults. In this cross-sectional study, we aimed to study how adiponectin and leptin were associated with lung function and atopic sensitisation in adolescents. The study included 384 children at mean age 12.9 years with measurements of adiponectin, leptin, lung function and atopic sensitisation. Adiponectin and leptin levels were measured in serum, lung function was measured by spirometry and atopic sensitisation was measured by serum specific Immunoglobulin E. In linear regression models, leptin was negatively associated with forced vital capacity (FVC) (Beta: -4.13; 95% Confidence Interval: -5.83, -2.44, P < 0.001) and forced expiratory volume in the first second (FEV) (-3.74; -5.39, -2.09, P < 0.001) after adjusting for body mass index (BMI) and other covariates. No associations were observed between adiponectin and lung function or between leptin or adiponectin and atopic sensitisation. In this cross-sectional analysis of adolescents in all weight classes, leptin was negatively associated with FEV and FVC independent of BMI, but no associations were found between adiponectin and lung function. The results suggest that leptin may have a functional role in the airways of healthy children.
炎症和机械作用都被认为可以解释肥胖儿童和成人哮喘风险增加和肺功能降低。关于肥胖在特应性和过敏发病机制中的潜在作用的证据则更加矛盾。脂联素和瘦素是脂肪代谢的炎症标志物，它们可能与肥胖儿童和成人哮喘风险增加和肺功能降低有关。在这项横断面研究中，我们旨在研究脂联素和瘦素与青少年肺功能和特应性致敏之间的关系。该研究纳入了 384 名平均年龄为 12.9 岁的儿童，对他们进行了脂联素、瘦素、肺功能和特应性致敏的测量。在血清中测量脂联素和瘦素水平，通过肺活量计测量肺功能，通过血清特异性免疫球蛋白 E 测量特应性致敏。在线性回归模型中，瘦素与用力肺活量（FVC）呈负相关（β：-4.13；95%置信区间：-5.83，-2.44，P<0.001），与第一秒用力呼气量（FEV）呈负相关（β：-3.74；-5.39，-2.09，P<0.001），在调整了体重指数（BMI）和其他协变量后。脂联素与肺功能之间、瘦素与脂联素与特应性致敏之间均无相关性。在这项对所有体重类别的青少年进行的横断面分析中，瘦素与 FEV 和 FVC 呈负相关，与 BMI 无关，但脂联素与肺功能之间无相关性。这些结果表明，瘦素可能在健康儿童的气道中具有功能作用。
