Department of Urology, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, 27157, USA.
Fertil Steril. 2012 Jul;98(1):21-9. doi: 10.1016/j.fertnstert.2012.05.038.
Regenerative medicine and tissue engineering technology may soon offer new hope for patients with serious injuries and end-stage reproductive organ failure. Scientists are now applying the principles of cell transplantation, material science, and bioengineering to construct biological substitutes that can restore and maintain normal function in diseased and injured reproductive tissues. In addition, the stem cell field is advancing, and new discoveries in this field will lead to new therapeutic strategies. For example, newly discovered types of stem cells have been retrieved from uterine tissues such as amniotic fluid and placental stem cells. The process of therapeutic cloning and the creation of induced pluripotent cells provide still other potential sources of stem cells for cell-based tissue engineering applications. Although stem cells are still in the research phase, some therapies arising from tissue engineering endeavors that make use of autologous adult cells have already entered the clinic. This article discusses these tissue engineering strategies for various organs in the male and female reproductive tract.
再生医学和组织工程技术可能很快为严重损伤和终末期生殖器官衰竭的患者带来新的希望。科学家们现在正在应用细胞移植、材料科学和生物工程的原理来构建生物替代品，以恢复和维持患病和受损生殖组织的正常功能。此外，干细胞领域正在取得进展，该领域的新发现将带来新的治疗策略。例如，从羊水和胎盘干细胞等子宫组织中提取了新发现的干细胞类型。治疗性克隆和诱导多能细胞的创建为基于细胞的组织工程应用提供了更多潜在的干细胞来源。尽管干细胞仍处于研究阶段，但一些利用自体成体细胞的组织工程努力所产生的疗法已经进入临床应用。本文讨论了这些用于男性和女性生殖道各个器官的组织工程策略。
