Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA.
Eur Neuropsychopharmacol. 2013 May;23(5):351-7. doi: 10.1016/j.euroneuro.2012.05.016. Epub 2012 Jun 28.
The primary focus of the current report was to determine if there was an association between LSC-R and ASI-Lite scores in cocaine-dependent individuals. The secondary focus was to determine if any demographic/drug use variables or comorbid psychiatric diagnoses (e.g. alcohol-dependence, mood disorders) were associated with higher LSC-R or ASI-Lite scores. We hypothesized that scores on the LSC-R would be positively correlated with ASI-Lite scores.
The sample included 239 cocaine-dependent individuals. The primary assessments administered were the LSC-R, the ASI-Lite, and the demographic/drug use questionnaire.
Simple linear regression revealed that total lifetime stress was positively and significantly correlated with total ASI-Lite scores; however, the r(2) value was very low indicating that this relationship is more likely explained by other factors. It was also determined that participants with a diagnosis of alcohol dependence versus those that did not had significantly higher ASI-Lite scores (even when the alcohol composite score was included as a covariate). Participants with a diagnosis of a mood disorder versus those who did not had significantly higher LSC-R scores and females had significantly higher LSC-R scores when compared to males. After performing a median split, those cocaine users with High LSC scores had significantly higher Beck Depression Inventory-II scores, total ASI-Lite scores, and Fagerström Test of Nicotine Dependence scores when compared to those individuals with Low LSC scores. Further analysis of the ASI-Lite demonstrated that composite scores in the domains of Medical, Drug, Legal, Family and Social Status, and Psychiatric were all significantly elevated in the High LSC group.
Overall, those with higher lifetime stress demonstrated higher addiction severity and depressive symptoms versus those that endorsed lower lifetime stress. Thus, additional research should be conducted investigating the impact stressful life events has on drug use patterns and characteristics.
本报告的主要重点是确定可卡因依赖者的 LSC-R 与 ASI-Lite 评分之间是否存在关联。次要重点是确定任何人口统计学/药物使用变量或合并的精神科诊断（例如，酒精依赖，情绪障碍）是否与更高的 LSC-R 或 ASI-Lite 评分相关。我们假设 LSC-R 的分数将与 ASI-Lite 分数呈正相关。
该样本包括 239 名可卡因依赖者。主要评估包括 LSC-R、ASI-Lite 和人口统计学/药物使用问卷。
简单线性回归显示，总终身压力与总 ASI-Lite 评分呈正相关且显著相关；然而，r(2) 值非常低，表明这种关系更可能由其他因素解释。还确定了患有酒精依赖症的参与者与未患有酒精依赖症的参与者相比，ASI-Lite 评分显著更高（即使将酒精综合评分作为协变量包括在内）。与未患有情绪障碍的参与者相比，患有情绪障碍的参与者的 LSC-R 评分显著更高，女性的 LSC-R 评分也显著高于男性。在进行中位数分割后，与具有低 LSC 评分的个体相比，高 LSC 评分的可卡因使用者的贝克抑郁量表第二版评分，总 ASI-Lite 评分和 Fagerström 尼古丁依赖测试评分显著更高。对 ASI-Lite 的进一步分析表明，在高 LSC 组中，医疗，药物，法律，家庭和社会地位以及精神科领域的综合评分均显著升高。
总体而言，与报告较低的终身压力相比，终身压力较高的人表现出更高的成瘾严重程度和抑郁症状。因此，应进行更多的研究，以调查生活压力事件对药物使用模式和特征的影响。
